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• W2009935013 abstract "<h3>AIMS</h3> To determine whether the infiltrating cells in the vitreous and subretinal fluid of patients with proliferative vitreoretinopathy (PVR) express messenger RNA for various cytokines found in this condition. <h3>METHODS</h3> The presence of mRNA coding for HPRT, IL-6, IL-1β, IL-8, and TNFα was investigated in 20 vitreous and subretinal fluid (SRF) samples from patients with PVR by reverse transcriptase polymerase chain reaction (RT-PCR). 16 samples from patients with retinal detachment and macular holes were used as controls. <h3>RESULTS</h3> HPRT was detected in all samples of PVR and in 11 (69%) control cases. Patients with PVR demonstrated mRNA for the cytokines tested more often than controls. The difference was statistically significant. <h3>CONCLUSION</h3> The presence of mRNA encoding for IL-6, IL-1β, IL-8, and TNFα is significantly detected by RT-PCR in vitreous and SRF samples of patients with PVR, indicating local production of these cytokines by vitreous and SRF cells." @default.
• W2009935013 created "2016-06-24" @default.
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• W2009935013 date "1999-11-01" @default.
• W2009935013 modified "2023-09-23" @default.
• W2009935013 title "Detection of cytokine mRNA production in infiltrating cells in proliferative vitreoretinopathy using reverse transcription polymerase chain reaction" @default.
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• W2009935013 doi "https://doi.org/10.1136/bjo.83.11.1296" @default.
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