FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009935997> ?p ?o ?g. }

• W2009935997 endingPage "7051" @default.
• W2009935997 startingPage "7042" @default.
• W2009935997 abstract "The optimization of a series of benzimidazole glucokinase activators is described. We identified a novel and potent achiral benzimidazole derivative as an allosteric GK activator. This activator was designed and synthesized via removal of the chiral center of the lead compound, 6-(N-acylpyrrolidin-2-yl)benzimidazole. The activator exhibited good PK profiles in rats and dogs, and significant hypoglycemic efficacy at 1 mg/kg po dosing in a rat OGTT model. The binding site and binding mode of the benzimidazole class of GKA with GK protein was confirmed by X-ray crystallographic analysis." @default.
• W2009935997 created "2016-06-24" @default.
• W2009935997 creator A5005262122 @default.
• W2009935997 creator A5007213833 @default.
• W2009935997 creator A5008916675 @default.
• W2009935997 creator A5012937443 @default.
• W2009935997 creator A5020247828 @default.
• W2009935997 creator A5037081977 @default.
• W2009935997 creator A5043775960 @default.
• W2009935997 creator A5064032463 @default.
• W2009935997 creator A5066278543 @default.
• W2009935997 creator A5078648312 @default.
• W2009935997 creator A5090208688 @default.
• W2009935997 creator A5091645476 @default.
• W2009935997 date "2009-10-01" @default.
• W2009935997 modified "2023-10-01" @default.
• W2009935997 title "The design and optimization of a series of 2-(pyridin-2-yl)-1H-benzimidazole compounds as allosteric glucokinase activators" @default.
• W2009935997 cites W1967212771 @default.
• W2009935997 cites W1974277291 @default.
• W2009935997 cites W1990888519 @default.
• W2009935997 cites W1993854596 @default.
• W2009935997 cites W2001641653 @default.
• W2009935997 cites W2043914375 @default.
• W2009935997 cites W2047889566 @default.
• W2009935997 cites W2050051162 @default.
• W2009935997 cites W2050317665 @default.
• W2009935997 cites W2076603607 @default.
• W2009935997 cites W2077257470 @default.
• W2009935997 cites W2089351119 @default.
• W2009935997 cites W2091992338 @default.
• W2009935997 cites W2094732496 @default.
• W2009935997 cites W2112040506 @default.
• W2009935997 cites W2114124488 @default.
• W2009935997 cites W2134141050 @default.
• W2009935997 cites W2164306929 @default.
• W2009935997 cites W2176018649 @default.
• W2009935997 cites W4206226084 @default.
• W2009935997 cites W4248884236 @default.
• W2009935997 doi "https://doi.org/10.1016/j.bmc.2009.05.037" @default.
• W2009935997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19736020" @default.
• W2009935997 hasPublicationYear "2009" @default.
• W2009935997 type Work @default.
• W2009935997 sameAs 2009935997 @default.
• W2009935997 citedByCount "29" @default.
• W2009935997 countsByYear W20099359972012 @default.
• W2009935997 countsByYear W20099359972013 @default.
• W2009935997 countsByYear W20099359972014 @default.
• W2009935997 countsByYear W20099359972015 @default.
• W2009935997 countsByYear W20099359972016 @default.
• W2009935997 countsByYear W20099359972018 @default.
• W2009935997 countsByYear W20099359972019 @default.
• W2009935997 countsByYear W20099359972020 @default.
• W2009935997 countsByYear W20099359972021 @default.
• W2009935997 countsByYear W20099359972023 @default.
• W2009935997 crossrefType "journal-article" @default.
• W2009935997 hasAuthorship W2009935997A5005262122 @default.
• W2009935997 hasAuthorship W2009935997A5007213833 @default.
• W2009935997 hasAuthorship W2009935997A5008916675 @default.
• W2009935997 hasAuthorship W2009935997A5012937443 @default.
• W2009935997 hasAuthorship W2009935997A5020247828 @default.
• W2009935997 hasAuthorship W2009935997A5037081977 @default.
• W2009935997 hasAuthorship W2009935997A5043775960 @default.
• W2009935997 hasAuthorship W2009935997A5064032463 @default.
• W2009935997 hasAuthorship W2009935997A5066278543 @default.
• W2009935997 hasAuthorship W2009935997A5078648312 @default.
• W2009935997 hasAuthorship W2009935997A5090208688 @default.
• W2009935997 hasAuthorship W2009935997A5091645476 @default.
• W2009935997 hasConcept C166342909 @default.
• W2009935997 hasConcept C170493617 @default.
• W2009935997 hasConcept C178790620 @default.
• W2009935997 hasConcept C181199279 @default.
• W2009935997 hasConcept C185592680 @default.
• W2009935997 hasConcept C21951064 @default.
• W2009935997 hasConcept C2778484023 @default.
• W2009935997 hasConcept C55493867 @default.
• W2009935997 hasConcept C71240020 @default.
• W2009935997 hasConcept C88045685 @default.
• W2009935997 hasConcept C98335778 @default.
• W2009935997 hasConceptScore W2009935997C166342909 @default.
• W2009935997 hasConceptScore W2009935997C170493617 @default.
• W2009935997 hasConceptScore W2009935997C178790620 @default.
• W2009935997 hasConceptScore W2009935997C181199279 @default.
• W2009935997 hasConceptScore W2009935997C185592680 @default.
• W2009935997 hasConceptScore W2009935997C21951064 @default.
• W2009935997 hasConceptScore W2009935997C2778484023 @default.
• W2009935997 hasConceptScore W2009935997C55493867 @default.
• W2009935997 hasConceptScore W2009935997C71240020 @default.
• W2009935997 hasConceptScore W2009935997C88045685 @default.
• W2009935997 hasConceptScore W2009935997C98335778 @default.
• W2009935997 hasIssue "19" @default.
• W2009935997 hasLocation W20099359971 @default.
• W2009935997 hasLocation W20099359972 @default.
• W2009935997 hasOpenAccess W2009935997 @default.
• W2009935997 hasPrimaryLocation W20099359971 @default.
• W2009935997 hasRelatedWork W1989585701 @default.
• W2009935997 hasRelatedWork W2009935997 @default.
• W2009935997 hasRelatedWork W2016627433 @default.
• W2009935997 hasRelatedWork W2018073268 @default.

• next