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• W2009945174 abstract "We investigated the EGL-30 (Gqα) pathway in C. elegans by using genetic screens to identify genes that confer phenotypes similar to egl-30 mutants. One such gene, egl-8, encodes a phospholipase Cβ that is present throughout the nervous system and near intestinal cell junctions. EGL-30 and EGL-8 appear to positively regulate synaptic transmission because reducing their function results in strong aldicarb resistance and slow locomotion rates. In contrast, GOA-1 (Goα) and DGK-1 (diacylglycerol kinase) appear to negatively regulate synaptic transmission, because reducing their function results in strong aldicarb hypersensitivity and hyperactive locomotion. A genetic analysis suggests that GOA-1 negatively regulates the EGL-30 pathway and that DGK-1 antagonizes the EGL-30 pathway." @default.
• W2009945174 created "2016-06-24" @default.
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• W2009945174 date "1999-10-01" @default.
• W2009945174 modified "2023-10-03" @default.
• W2009945174 title "Goα and Diacylglycerol Kinase Negatively Regulate the Gqα Pathway in C. elegans" @default.
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• W2009945174 doi "https://doi.org/10.1016/s0896-6273(00)80847-8" @default.
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