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• W2009949766 abstract "The effect of lanthanum (La) on kainate (KA) responses in neurons acutely dissociated from the rat sacral dorsal commissural nucleus (SDCN) was investigated using the nystatin-perforated patch-recording configuration under voltage-clamp conditions. The responses to KA were mediated by activation of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in SDCN neurons. La3+ reversibly inhibited KA (100 µM) activated currents (IKA) in a concentration-dependent manner over the range from 30 µM to 30 mM, with IC50 values of 0.64 ± 0.06 mM at a holding potential (VH) of –40 mV. Our further study indicated that the effects of La3+ on IKA were voltage independent. Moreover, the inhibition was not use dependent and was not overcome by increasing the concentration of agonist. These findings indicate that La3+ is an efficacious inhibitor of AMPA receptor mediated responses which may contribute to its cytotoxic effect." @default.
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• W2009949766 date "2004-01-01" @default.
• W2009949766 modified "2023-09-24" @default.
• W2009949766 title "Suppression of Kainate-Evoked AMPA Receptor Mediated Responses by Lanthanum in Rat Sacral Dorsal Commissural Neurons" @default.
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• W2009949766 doi "https://doi.org/10.1159/000079340" @default.
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