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- W2009957319 abstract "Genome duality in ciliated protozoa offers a unique system to showcase their epigenome as a model of inheritance. In Oxytricha, the somatic genome is responsible for vegetative growth, whereas the germline contributes DNA to the next sexual generation. Somatic nuclear development removes all transposons and other so-called junk DNA, which comprise ~95% of the germline. We demonstrate that Piwi-interacting small RNAs (piRNAs) from the maternal nucleus can specify genomic regions for retention in this process. Oxytricha piRNAs map primarily to the somatic genome, representing the ~5% of the germline that is retained. Furthermore, injection of synthetic piRNAs corresponding to normally deleted regions leads to their retention in later generations. Our findings highlight small RNAs as powerful transgenerational carriers of epigenetic information for genome programming." @default.
- W2009957319 created "2016-06-24" @default.
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- W2009957319 creator A5044820964 @default.
- W2009957319 creator A5073999639 @default.
- W2009957319 creator A5089614549 @default.
- W2009957319 date "2012-12-01" @default.
- W2009957319 modified "2023-10-16" @default.
- W2009957319 title "Piwi-Interacting RNAs Protect DNA against Loss during Oxytricha Genome Rearrangement" @default.
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- W2009957319 doi "https://doi.org/10.1016/j.cell.2012.10.045" @default.
- W2009957319 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3678556" @default.
- W2009957319 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23217708" @default.
- W2009957319 hasPublicationYear "2012" @default.
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