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• W2009968192 abstract "Kirsten murine sarcoma virus (Ki-MSV) is a replication-defective recombinant retrovirus capable of transforming cells in culture. A Ki-MSV coded, 21,000-dalton protein (p21ras) is required for the maintenance of cellular transformation. It is unknown whether the p2lras of Ki-MSV induces transformation by acting on multiple targets, as has been suggested for Rous sarcoma virus transformed cells, or by a single target mechanism. In order to resolve this question, we have used a normal rat kidney cell line transformed by a temperature-sensitive mutant strain of Ki-MSV (tsKNRK), which codes for a thermolabile p21ras to investigate the correlative aspects of the expression of several transformation-related cellular properties upon shifting from the permissive (32°) to nonpermissive (39°) temperature. Except for an altered morphology, an organized cytoskeleton, and increased adhesion to substratum, tsKNRK cells at 32° displayed similar properties to those of wild-type Ki-MSV transformants at either temperature. Upon shifting to 39°, anchorage- and density-dependent growth were restored, although the growth rate and glucose uptake were unaffected. The cells assumed a more flattened morphology, although adhesiveness did not increase significantly. Increased levels of cell surface fibronectin were observed within 48 hr post-temperature shift, although fibronectin levels comparable to that of normal rat kidney cells (NRK) were not observed until later. Epidermal growth factor (EGF) binding increased only slightly at 48 hr post-temperature shift, but did not approach EGF-binding levels of NRK cells. Cytoskeletal organization was invariant between the two temperatures. Although our results suggest a multiple target model for Ki-MSV-mediated transformation, a single target mechanism cannot totally be ruled out." @default.
• W2009968192 created "2016-06-24" @default.
• W2009968192 creator A5017821194 @default.
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• W2009968192 date "1982-09-01" @default.
• W2009968192 modified "2023-10-16" @default.
• W2009968192 title "Kirsten murine sarcoma virus-coded p21ras may act on multiple targets to effect pleiotropic changes in transformed cells" @default.
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• W2009968192 doi "https://doi.org/10.1016/0042-6822(82)90172-6" @default.
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