FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009968555> ?p ?o ?g. }

• W2009968555 endingPage "e54449" @default.
• W2009968555 startingPage "e54449" @default.
• W2009968555 abstract "Tooth root formation begins after the completion of crown morphogenesis. At the end edge of the tooth crown, inner and outer enamel epithelia form Hertwig’s epithelial root sheath (HERS). HERS extends along with dental follicular tissue for root formation. Ameloblastin (AMBN) is an enamel matrix protein secreted by ameloblasts and HERS derived cells. A number of enamel proteins are eliminated in root formation, except for AMBN. AMBN may be related to tooth root formation; however, its role in this process remains unclear. In this study, we found AMBN in the basal portion of HERS of lower first molar in mice, but not at the tip. We designed and synthesized small interfering RNA (siRNA) targeting AMBN based on the mouse sequence. When AMBN siRNA was injected into a prospective mandibular first molar of postnatal day 10 mice, the root became shorter 10 days later. Furthermore, HERS in these mice revealed a multilayered appearance and 5-bromo-2′-deoxyuridine (BrdU) positive cells increased in the outer layers. In vitro experiments, when cells were compared with and without transiently expressing AMBN mRNA, expression of growth suppressor genes such as p21Cip1 and p27Kip1 was enhanced without AMBN and BrdU incorporation increased. Thus, AMBN may regulate differentiation state of HERS derived cells. Moreover, our results suggest that the expression of AMBN in HERS functions as a trigger for normal root formation." @default.
• W2009968555 created "2016-06-24" @default.
• W2009968555 creator A5013022681 @default.
• W2009968555 creator A5021322220 @default.
• W2009968555 creator A5037601029 @default.
• W2009968555 creator A5039161969 @default.
• W2009968555 creator A5043027289 @default.
• W2009968555 creator A5069883361 @default.
• W2009968555 creator A5072576439 @default.
• W2009968555 creator A5073265458 @default.
• W2009968555 date "2013-01-23" @default.
• W2009968555 modified "2023-09-25" @default.
• W2009968555 title "Ameloblastin in Hertwig’s Epithelial Root Sheath Regulates Tooth Root Formation and Development" @default.
• W2009968555 cites W1972075126 @default.
• W2009968555 cites W1972318351 @default.
• W2009968555 cites W1973674048 @default.
• W2009968555 cites W1993475011 @default.
• W2009968555 cites W2009356614 @default.
• W2009968555 cites W2010795325 @default.
• W2009968555 cites W2013097065 @default.
• W2009968555 cites W2013576617 @default.
• W2009968555 cites W2016742697 @default.
• W2009968555 cites W2019423191 @default.
• W2009968555 cites W2037343712 @default.
• W2009968555 cites W2040285649 @default.
• W2009968555 cites W2047979339 @default.
• W2009968555 cites W2048603790 @default.
• W2009968555 cites W2052081888 @default.
• W2009968555 cites W2054971453 @default.
• W2009968555 cites W2083974808 @default.
• W2009968555 cites W2089221894 @default.
• W2009968555 cites W2104927261 @default.
• W2009968555 cites W2125237611 @default.
• W2009968555 cites W2132594991 @default.
• W2009968555 cites W2145663349 @default.
• W2009968555 cites W2155480894 @default.
• W2009968555 cites W2163404165 @default.
• W2009968555 doi "https://doi.org/10.1371/journal.pone.0054449" @default.
• W2009968555 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3553119" @default.
• W2009968555 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23372724" @default.
• W2009968555 hasPublicationYear "2013" @default.
• W2009968555 type Work @default.
• W2009968555 sameAs 2009968555 @default.
• W2009968555 citedByCount "12" @default.
• W2009968555 countsByYear W20099685552014 @default.
• W2009968555 countsByYear W20099685552015 @default.
• W2009968555 countsByYear W20099685552016 @default.
• W2009968555 countsByYear W20099685552017 @default.
• W2009968555 countsByYear W20099685552018 @default.
• W2009968555 countsByYear W20099685552021 @default.
• W2009968555 crossrefType "journal-article" @default.
• W2009968555 hasAuthorship W2009968555A5013022681 @default.
• W2009968555 hasAuthorship W2009968555A5021322220 @default.
• W2009968555 hasAuthorship W2009968555A5037601029 @default.
• W2009968555 hasAuthorship W2009968555A5039161969 @default.
• W2009968555 hasAuthorship W2009968555A5043027289 @default.
• W2009968555 hasAuthorship W2009968555A5069883361 @default.
• W2009968555 hasAuthorship W2009968555A5072576439 @default.
• W2009968555 hasAuthorship W2009968555A5073265458 @default.
• W2009968555 hasBestOaLocation W20099685551 @default.
• W2009968555 hasConcept C104392178 @default.
• W2009968555 hasConcept C153911025 @default.
• W2009968555 hasConcept C156887251 @default.
• W2009968555 hasConcept C185592680 @default.
• W2009968555 hasConcept C199343813 @default.
• W2009968555 hasConcept C2777894202 @default.
• W2009968555 hasConcept C2779263046 @default.
• W2009968555 hasConcept C56302369 @default.
• W2009968555 hasConcept C71924100 @default.
• W2009968555 hasConcept C86803240 @default.
• W2009968555 hasConcept C95444343 @default.
• W2009968555 hasConceptScore W2009968555C104392178 @default.
• W2009968555 hasConceptScore W2009968555C153911025 @default.
• W2009968555 hasConceptScore W2009968555C156887251 @default.
• W2009968555 hasConceptScore W2009968555C185592680 @default.
• W2009968555 hasConceptScore W2009968555C199343813 @default.
• W2009968555 hasConceptScore W2009968555C2777894202 @default.
• W2009968555 hasConceptScore W2009968555C2779263046 @default.
• W2009968555 hasConceptScore W2009968555C56302369 @default.
• W2009968555 hasConceptScore W2009968555C71924100 @default.
• W2009968555 hasConceptScore W2009968555C86803240 @default.
• W2009968555 hasConceptScore W2009968555C95444343 @default.
• W2009968555 hasIssue "1" @default.
• W2009968555 hasLocation W20099685551 @default.
• W2009968555 hasLocation W20099685552 @default.
• W2009968555 hasLocation W20099685553 @default.
• W2009968555 hasLocation W20099685554 @default.
• W2009968555 hasLocation W20099685555 @default.
• W2009968555 hasOpenAccess W2009968555 @default.
• W2009968555 hasPrimaryLocation W20099685551 @default.
• W2009968555 hasRelatedWork W1984354082 @default.
• W2009968555 hasRelatedWork W1994223078 @default.
• W2009968555 hasRelatedWork W2004473623 @default.
• W2009968555 hasRelatedWork W2024808769 @default.
• W2009968555 hasRelatedWork W2056145075 @default.
• W2009968555 hasRelatedWork W2084942376 @default.
• W2009968555 hasRelatedWork W2130525880 @default.
• W2009968555 hasRelatedWork W2155007158 @default.

• next