Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009969297> ?p ?o ?g. }
- W2009969297 endingPage "652" @default.
- W2009969297 startingPage "639" @default.
- W2009969297 abstract "The AAA + (ATPases associated with a variety of cellular activities) superfamily protein ClpC is a key regulator of cell development in Bacillus subtilis. As part of a large oligomeric complex, ClpC controls an array of cellular processes by recognizing, unfolding, and providing misfolded and aggregated proteins as substrates for the ClpP peptidase. ClpC is unique compared to other HSP100/Clp proteins, as it requires an adaptor protein for all fundamental activities. The NMR solution structure of the N-terminal repeat domain of ClpC (N-ClpCR) comprises two structural repeats of a four-helix motif. NMR experiments used to map the MecA adaptor protein interaction surface of N-ClpCR reveal that regions involved in the interaction possess conformational flexibility and conformational exchange on the microsecond-to-millisecond timescale. The electrostatic surface of N-ClpCR differs substantially from the N-domain of Escherichia coli ClpA and ClpB, suggesting that the electrostatic surface characteristics of HSP100/Clp N-domains may play a role in adaptor protein and substrate interaction specificity, and perhaps contribute to the unique adaptor protein requirement of ClpC." @default.
- W2009969297 created "2016-06-24" @default.
- W2009969297 creator A5027770327 @default.
- W2009969297 creator A5027838269 @default.
- W2009969297 creator A5032745836 @default.
- W2009969297 creator A5035882736 @default.
- W2009969297 creator A5060296168 @default.
- W2009969297 creator A5082180799 @default.
- W2009969297 creator A5089647104 @default.
- W2009969297 date "2009-04-01" @default.
- W2009969297 modified "2023-09-23" @default.
- W2009969297 title "Structural and Motional Contributions of the Bacillus subtilis ClpC N-Domain to Adaptor Protein Interactions" @default.
- W2009969297 cites W127412881 @default.
- W2009969297 cites W1589295940 @default.
- W2009969297 cites W1857769113 @default.
- W2009969297 cites W1966049553 @default.
- W2009969297 cites W1974735434 @default.
- W2009969297 cites W1975459052 @default.
- W2009969297 cites W1976948973 @default.
- W2009969297 cites W1978824717 @default.
- W2009969297 cites W1979663825 @default.
- W2009969297 cites W1980133582 @default.
- W2009969297 cites W1990695302 @default.
- W2009969297 cites W1991564440 @default.
- W2009969297 cites W1993402893 @default.
- W2009969297 cites W1994730950 @default.
- W2009969297 cites W1995017064 @default.
- W2009969297 cites W1997978648 @default.
- W2009969297 cites W2006395260 @default.
- W2009969297 cites W2008636063 @default.
- W2009969297 cites W2008708467 @default.
- W2009969297 cites W2010958487 @default.
- W2009969297 cites W2012689130 @default.
- W2009969297 cites W2012731700 @default.
- W2009969297 cites W2013973556 @default.
- W2009969297 cites W2022058405 @default.
- W2009969297 cites W2023689103 @default.
- W2009969297 cites W2029582401 @default.
- W2009969297 cites W2029953447 @default.
- W2009969297 cites W2031193335 @default.
- W2009969297 cites W2033042066 @default.
- W2009969297 cites W2036620942 @default.
- W2009969297 cites W2048822589 @default.
- W2009969297 cites W2053158030 @default.
- W2009969297 cites W2058505635 @default.
- W2009969297 cites W2059877647 @default.
- W2009969297 cites W2062557777 @default.
- W2009969297 cites W2068659723 @default.
- W2009969297 cites W2082176639 @default.
- W2009969297 cites W2085277871 @default.
- W2009969297 cites W2090054074 @default.
- W2009969297 cites W2096913764 @default.
- W2009969297 cites W2112103709 @default.
- W2009969297 cites W2115703815 @default.
- W2009969297 cites W2116687956 @default.
- W2009969297 cites W2119612051 @default.
- W2009969297 cites W2121861656 @default.
- W2009969297 cites W2122070718 @default.
- W2009969297 cites W2122339645 @default.
- W2009969297 cites W2126018533 @default.
- W2009969297 cites W2129879061 @default.
- W2009969297 cites W2136280642 @default.
- W2009969297 cites W2144047169 @default.
- W2009969297 cites W2144362290 @default.
- W2009969297 cites W2144908841 @default.
- W2009969297 cites W2153123993 @default.
- W2009969297 cites W2155921753 @default.
- W2009969297 cites W2156879354 @default.
- W2009969297 cites W2165327361 @default.
- W2009969297 cites W2165969670 @default.
- W2009969297 cites W2169821755 @default.
- W2009969297 cites W360295271 @default.
- W2009969297 cites W4245230758 @default.
- W2009969297 doi "https://doi.org/10.1016/j.jmb.2009.01.046" @default.
- W2009969297 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2692191" @default.
- W2009969297 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19361434" @default.
- W2009969297 hasPublicationYear "2009" @default.
- W2009969297 type Work @default.
- W2009969297 sameAs 2009969297 @default.
- W2009969297 citedByCount "18" @default.
- W2009969297 countsByYear W20099692972012 @default.
- W2009969297 countsByYear W20099692972013 @default.
- W2009969297 countsByYear W20099692972015 @default.
- W2009969297 countsByYear W20099692972016 @default.
- W2009969297 countsByYear W20099692972017 @default.
- W2009969297 countsByYear W20099692972018 @default.
- W2009969297 countsByYear W20099692972019 @default.
- W2009969297 countsByYear W20099692972022 @default.
- W2009969297 countsByYear W20099692972023 @default.
- W2009969297 crossrefType "journal-article" @default.
- W2009969297 hasAuthorship W2009969297A5027770327 @default.
- W2009969297 hasAuthorship W2009969297A5027838269 @default.
- W2009969297 hasAuthorship W2009969297A5032745836 @default.
- W2009969297 hasAuthorship W2009969297A5035882736 @default.
- W2009969297 hasAuthorship W2009969297A5060296168 @default.
- W2009969297 hasAuthorship W2009969297A5082180799 @default.
- W2009969297 hasAuthorship W2009969297A5089647104 @default.
- W2009969297 hasBestOaLocation W20099692972 @default.