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• W2009969702 abstract "A new method for the prediction of the drug release profiles during a running pellet coating process from in-line near infrared (NIR) measurements has been developed. The NIR spectra were acquired during a manufacturing process through an immersion probe. These spectra reflect the coating thickness that is inherently connected with the drug release. Pellets sampled at nine process time points from thirteen designed laboratory-scale coating batches were subjected to the dissolution testing. In the case of the pH-sensitive Acryl-EZE coating the drug release kinetics for the acidic medium has a sigmoid form with a pronounced induction period that tends to grow along with the coating thickness. In this work the autocatalytic model adopted from the chemical kinetics has been successfully applied to describe the drug release. A generalized interpretation of the kinetic constants in terms of the process and product parameters has been suggested. A combination of the kinetic model with the multivariate Partial Least Squares (PLS) regression enabled prediction of the release profiles from the process NIR data. The method can be used to monitor the final pellet quality in the course of a coating process." @default.
• W2009969702 created "2016-06-24" @default.
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• W2009969702 date "2011-01-01" @default.
• W2009969702 modified "2023-10-18" @default.
• W2009969702 title "In-line prediction of drug release profiles for pH-sensitive coated pellets" @default.
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• W2009969702 doi "https://doi.org/10.1039/c0an01033b" @default.
• W2009969702 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21968477" @default.
• W2009969702 hasPublicationYear "2011" @default.
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