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• W2009974968 abstract "Since the first reports of successful pregnancies after treatment with intra cytoplasmic sperm injection (ICSI) in humans, intensive investigations focused on the use of testicular spermatozoa and immature sperm cells in the treatment of azoopsermic patients. Several studies explore the technical development of the preparation, isolation and cryo storage of testicular germ cells. Other studies focus on ICSI itself and try to identify the biochemical and biophysical processes involved in fertilisation after injection of a testicular sperm cell into a human oocyte. Indications for azoospermic patients to whom this first line treatment can be offered are becoming more defined. But one of the major concerns is of course the safety of the technique, especially, for the health and reproductive life of the babies born after application of ICSI with testicular germ cells. An evaluation of ICSI with testicular germ cells is presented in this manuscript." @default.
• W2009974968 created "2016-06-24" @default.
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• W2009974968 date "2000-09-01" @default.
• W2009974968 modified "2023-09-23" @default.
• W2009974968 title "Biological aspects of testicular sperm extraction" @default.
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• W2009974968 doi "https://doi.org/10.1016/s0301-2115(00)00419-x" @default.
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