Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009983256> ?p ?o ?g. }
- W2009983256 endingPage "1510" @default.
- W2009983256 startingPage "1497" @default.
- W2009983256 abstract "In view of the possibility that ricin may be used as a bioweapon against human populations, we examined the pathological consequences that occur in mice after introduction of ricin into the pulmonary system. Intratracheal instillation of a lethal dose of ricin (20 microg/100 g body weight) resulted in a hemorrhagic inflammatory response in multiple organs, accompanied by activation of mitogen-activated protein kinases, increased synthesis of proinflammatory RNA transcripts, and increased levels of circulating cytokines and chemokines. A sublethal dose of instilled ricin (2 microg/100 g body weight) induced a similar response in lungs but did not cause detectable damage in other organs. Lungs of mice that recovered from a sublethal dose of ricin displayed evidence of fibrosis and residual damage. A lethal dose of ricin caused accumulation of proinflammatory RNA transcripts and substantial damage to 28S rRNA of multiple organs, including lung, kidney, spleen, liver, and blood, demonstrating that instilled ricin gained access to the circulation. The kidneys of mice instilled with a lethal dose of ricin showed accumulation of fibrin/fibrinogen in glomerular capillaries, increased numbers of glomerular leukocytes, and impairment of kidney function. A sublethal dose of ricin failed to induce damage to 28S rRNA in kidney or other extrapulmonary organs." @default.
- W2009983256 created "2016-06-24" @default.
- W2009983256 creator A5024317580 @default.
- W2009983256 creator A5036858877 @default.
- W2009983256 creator A5049675654 @default.
- W2009983256 creator A5082807809 @default.
- W2009983256 date "2007-05-01" @default.
- W2009983256 modified "2023-10-16" @default.
- W2009983256 title "Intrapulmonary Delivery of Ricin at High Dosage Triggers a Systemic Inflammatory Response and Glomerular Damage" @default.
- W2009983256 cites W109587293 @default.
- W2009983256 cites W1506955202 @default.
- W2009983256 cites W183993696 @default.
- W2009983256 cites W1875254393 @default.
- W2009983256 cites W1970480600 @default.
- W2009983256 cites W1971407740 @default.
- W2009983256 cites W1986060421 @default.
- W2009983256 cites W1986896480 @default.
- W2009983256 cites W2003288227 @default.
- W2009983256 cites W2009109048 @default.
- W2009983256 cites W2010281376 @default.
- W2009983256 cites W2010543202 @default.
- W2009983256 cites W2015730823 @default.
- W2009983256 cites W2018513502 @default.
- W2009983256 cites W2023402680 @default.
- W2009983256 cites W2025558566 @default.
- W2009983256 cites W2030063210 @default.
- W2009983256 cites W2032231580 @default.
- W2009983256 cites W2052901151 @default.
- W2009983256 cites W2074150439 @default.
- W2009983256 cites W2079076826 @default.
- W2009983256 cites W2095477785 @default.
- W2009983256 cites W2103345496 @default.
- W2009983256 cites W2119408080 @default.
- W2009983256 cites W2120166044 @default.
- W2009983256 cites W2120919686 @default.
- W2009983256 cites W2122057254 @default.
- W2009983256 cites W2127938920 @default.
- W2009983256 cites W2135555439 @default.
- W2009983256 cites W2143333940 @default.
- W2009983256 cites W2159648100 @default.
- W2009983256 cites W2160105753 @default.
- W2009983256 cites W2260189875 @default.
- W2009983256 cites W4230785217 @default.
- W2009983256 cites W4297846776 @default.
- W2009983256 cites W9714344 @default.
- W2009983256 cites W2098208958 @default.
- W2009983256 doi "https://doi.org/10.2353/ajpath.2007.060703" @default.
- W2009983256 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1854946" @default.
- W2009983256 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17456757" @default.
- W2009983256 hasPublicationYear "2007" @default.
- W2009983256 type Work @default.
- W2009983256 sameAs 2009983256 @default.
- W2009983256 citedByCount "61" @default.
- W2009983256 countsByYear W20099832562012 @default.
- W2009983256 countsByYear W20099832562013 @default.
- W2009983256 countsByYear W20099832562014 @default.
- W2009983256 countsByYear W20099832562015 @default.
- W2009983256 countsByYear W20099832562016 @default.
- W2009983256 countsByYear W20099832562017 @default.
- W2009983256 countsByYear W20099832562018 @default.
- W2009983256 countsByYear W20099832562019 @default.
- W2009983256 countsByYear W20099832562020 @default.
- W2009983256 countsByYear W20099832562021 @default.
- W2009983256 countsByYear W20099832562022 @default.
- W2009983256 countsByYear W20099832562023 @default.
- W2009983256 crossrefType "journal-article" @default.
- W2009983256 hasAuthorship W2009983256A5024317580 @default.
- W2009983256 hasAuthorship W2009983256A5036858877 @default.
- W2009983256 hasAuthorship W2009983256A5049675654 @default.
- W2009983256 hasAuthorship W2009983256A5082807809 @default.
- W2009983256 hasBestOaLocation W20099832561 @default.
- W2009983256 hasConcept C134018914 @default.
- W2009983256 hasConcept C142724271 @default.
- W2009983256 hasConcept C164027704 @default.
- W2009983256 hasConcept C203014093 @default.
- W2009983256 hasConcept C2776914184 @default.
- W2009983256 hasConcept C2777200438 @default.
- W2009983256 hasConcept C2777367657 @default.
- W2009983256 hasConcept C2777544843 @default.
- W2009983256 hasConcept C2780091579 @default.
- W2009983256 hasConcept C2780931953 @default.
- W2009983256 hasConcept C33070731 @default.
- W2009983256 hasConcept C71924100 @default.
- W2009983256 hasConcept C86803240 @default.
- W2009983256 hasConcept C89423630 @default.
- W2009983256 hasConceptScore W2009983256C134018914 @default.
- W2009983256 hasConceptScore W2009983256C142724271 @default.
- W2009983256 hasConceptScore W2009983256C164027704 @default.
- W2009983256 hasConceptScore W2009983256C203014093 @default.
- W2009983256 hasConceptScore W2009983256C2776914184 @default.
- W2009983256 hasConceptScore W2009983256C2777200438 @default.
- W2009983256 hasConceptScore W2009983256C2777367657 @default.
- W2009983256 hasConceptScore W2009983256C2777544843 @default.
- W2009983256 hasConceptScore W2009983256C2780091579 @default.
- W2009983256 hasConceptScore W2009983256C2780931953 @default.
- W2009983256 hasConceptScore W2009983256C33070731 @default.
- W2009983256 hasConceptScore W2009983256C71924100 @default.
- W2009983256 hasConceptScore W2009983256C86803240 @default.