Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010000445> ?p ?o ?g. }
- W2010000445 endingPage "727" @default.
- W2010000445 startingPage "713" @default.
- W2010000445 abstract "Cellular functions of an organism are maintained by protein-protein interactions. Those proteins that bind multiple partners asynchronously (date hub proteins) are important to make the interaction network coordinated. It is known that many date hub proteins bind different partners at overlapping (OV) interfaces. To understand how OV interfaces of date hub proteins can recognize multiple partners, we analyzed the difference between OV and non-overlapping (Non-OV) regions of interfaces involved in the binding of different partners. By using the structures of 16 date hub proteins with various interaction partners (ranging from 5 to 33), we compared buried surface area, compositions of amino acid residues and secondary structures, and side-chain orientations. It was found that buried interface residues are important for recognizing multiple partners, while exposed interface residues are important for determining specificity to a particular ligand. In addition, our analyses reveal that residue compositions in OV and Non-OV regions are different and that residues in OV region show diverse side-chain torsion angles to accommodate binding to multiple targets." @default.
- W2010000445 created "2016-06-24" @default.
- W2010000445 creator A5035143113 @default.
- W2010000445 creator A5063144451 @default.
- W2010000445 creator A5080613861 @default.
- W2010000445 date "2011-08-01" @default.
- W2010000445 modified "2023-09-25" @default.
- W2010000445 title "Distinct Roles of Overlapping and Non-overlapping Regions of Hub Protein Interfaces in Recognition of Multiple Partners" @default.
- W2010000445 cites W1935467915 @default.
- W2010000445 cites W1971266373 @default.
- W2010000445 cites W1976261957 @default.
- W2010000445 cites W1985153601 @default.
- W2010000445 cites W1985563952 @default.
- W2010000445 cites W1996559970 @default.
- W2010000445 cites W2008708467 @default.
- W2010000445 cites W2010485601 @default.
- W2010000445 cites W2012852001 @default.
- W2010000445 cites W2015802360 @default.
- W2010000445 cites W2017016843 @default.
- W2010000445 cites W2021226373 @default.
- W2010000445 cites W2037624771 @default.
- W2010000445 cites W2047572594 @default.
- W2010000445 cites W2051230054 @default.
- W2010000445 cites W2075770210 @default.
- W2010000445 cites W2081639575 @default.
- W2010000445 cites W2086122085 @default.
- W2010000445 cites W2087487725 @default.
- W2010000445 cites W2093642677 @default.
- W2010000445 cites W2097985410 @default.
- W2010000445 cites W2098164044 @default.
- W2010000445 cites W2104437738 @default.
- W2010000445 cites W2119087770 @default.
- W2010000445 cites W2127119917 @default.
- W2010000445 cites W2130253098 @default.
- W2010000445 cites W2130790725 @default.
- W2010000445 cites W2132178599 @default.
- W2010000445 cites W2132582966 @default.
- W2010000445 cites W2137015675 @default.
- W2010000445 cites W2146442590 @default.
- W2010000445 cites W2147068690 @default.
- W2010000445 cites W2150066952 @default.
- W2010000445 cites W2150306348 @default.
- W2010000445 cites W2151270191 @default.
- W2010000445 cites W2151323530 @default.
- W2010000445 cites W2156125289 @default.
- W2010000445 cites W2158714788 @default.
- W2010000445 cites W2167867998 @default.
- W2010000445 cites W2170587249 @default.
- W2010000445 cites W2170872475 @default.
- W2010000445 doi "https://doi.org/10.1016/j.jmb.2011.06.027" @default.
- W2010000445 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21723293" @default.
- W2010000445 hasPublicationYear "2011" @default.
- W2010000445 type Work @default.
- W2010000445 sameAs 2010000445 @default.
- W2010000445 citedByCount "19" @default.
- W2010000445 countsByYear W20100004452012 @default.
- W2010000445 countsByYear W20100004452013 @default.
- W2010000445 countsByYear W20100004452014 @default.
- W2010000445 countsByYear W20100004452016 @default.
- W2010000445 countsByYear W20100004452018 @default.
- W2010000445 countsByYear W20100004452021 @default.
- W2010000445 countsByYear W20100004452022 @default.
- W2010000445 crossrefType "journal-article" @default.
- W2010000445 hasAuthorship W2010000445A5035143113 @default.
- W2010000445 hasAuthorship W2010000445A5063144451 @default.
- W2010000445 hasAuthorship W2010000445A5080613861 @default.
- W2010000445 hasBestOaLocation W20100004451 @default.
- W2010000445 hasConcept C104317684 @default.
- W2010000445 hasConcept C107824862 @default.
- W2010000445 hasConcept C11804247 @default.
- W2010000445 hasConcept C167625842 @default.
- W2010000445 hasConcept C178790620 @default.
- W2010000445 hasConcept C185592680 @default.
- W2010000445 hasConcept C204921945 @default.
- W2010000445 hasConcept C2994376932 @default.
- W2010000445 hasConcept C47701112 @default.
- W2010000445 hasConcept C515207424 @default.
- W2010000445 hasConcept C51639874 @default.
- W2010000445 hasConcept C521977710 @default.
- W2010000445 hasConcept C54355233 @default.
- W2010000445 hasConcept C55493867 @default.
- W2010000445 hasConcept C70721500 @default.
- W2010000445 hasConcept C86803240 @default.
- W2010000445 hasConcept C95444343 @default.
- W2010000445 hasConceptScore W2010000445C104317684 @default.
- W2010000445 hasConceptScore W2010000445C107824862 @default.
- W2010000445 hasConceptScore W2010000445C11804247 @default.
- W2010000445 hasConceptScore W2010000445C167625842 @default.
- W2010000445 hasConceptScore W2010000445C178790620 @default.
- W2010000445 hasConceptScore W2010000445C185592680 @default.
- W2010000445 hasConceptScore W2010000445C204921945 @default.
- W2010000445 hasConceptScore W2010000445C2994376932 @default.
- W2010000445 hasConceptScore W2010000445C47701112 @default.
- W2010000445 hasConceptScore W2010000445C515207424 @default.
- W2010000445 hasConceptScore W2010000445C51639874 @default.
- W2010000445 hasConceptScore W2010000445C521977710 @default.
- W2010000445 hasConceptScore W2010000445C54355233 @default.
- W2010000445 hasConceptScore W2010000445C55493867 @default.