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- W2010014312 abstract "Lipoprotein(a) [Lp(a)] is considered an independent risk factor for cardiovascular disease. Its concentration is mainly determined by the kringle-IV repeat copy number variation (CNV) at the apolipoprotein(a) [apo(a)] locus. We aimed to investigate the immediate effect of weight reduction on plasma Lp(a) levels and its dependency on the apo(a) CNV in obese children. We performed a prospective longitudinal intervention study of a low-fat hypocaloric diet conducted in a 3-week dietary camp for obese children. In all, 140 obese participants (54 boys and 86 girls) with a mean age of 12.5±1.6 years and a mean relative body mass index (BMI) before treatment of 165.6±24.7% were included. Body weight and plasma levels of Lp(a), lipids, apolipoproteins A–I and B, insulin, and C-reactive protein were determined before the onset and after the end of the intervention. In addition, the number of apo(a) kringle-IV repeats were determined using sodium dodecyl sulfate agarose gel electrophoresis. The mean loss of body weight was 5.0±1.3 kg (−6.6%), resulting in a mean decrease of the relative BMI of 6.6%. Blood chemistry revealed significant changes in all parameters, especially in Lp(a), with a decrease from 24.4±30.6 to 17.9±22.6 mg per 100 ml or −19% (P<0.001). The decrease of Lp(a) levels was higher in the group with low compared with high molecular weight apo(a) phenotypes (−23.9 vs −16.6%). Weight reduction in obese children is associated with significant changes in Lp(a) levels, especially in subjects with high pre-treatment Lp(a) concentrations. This effect is markedly influenced by the molecular phenotype at the copy-number variable apo(a) locus." @default.
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- W2010014312 date "2009-07-28" @default.
- W2010014312 modified "2023-10-16" @default.
- W2010014312 title "Decrease of Lp(a) during weight reduction in obese children is modified by the apo(a) kringle-IV copy number variation" @default.
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- W2010014312 doi "https://doi.org/10.1038/ijo.2009.144" @default.
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