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• W2010014978 abstract "P-glycoprotein (P-gp), a transmembrane permeability glycoprotein, is a member of ATP binding cassette (ABC) super family that functions specifically as a carrier mediated primary active efflux transporter. It is widely distributed throughout the body and has a diverse range of substrates. Several vital therapeutic agents are substrates to P-gp and their bioavailability is lowered or a resistance is induced because of the protein efflux. Hence P-gp inhibitors were explored for overcoming multidrug resistance and poor bioavailability problems of the therapeutic P-gp substrates. The sensitivity of drug moieties to P-gp and vice versa can be established by various experimental models in silico, in vitro and in vivo. Ever since the discovery of P-gp, the research plethora identified several chemical structures as P-gp inhibitors. The aim of this review was to emphasize on the discovery and development of newer, inert, non-toxic, and more efficient, specifically targeting P-gp inhibitors, like those among the natural herb extracts, pharmaceutical excipients and formulations, and other rational drug moieties. The applications of cellular and molecular biology knowledge, in silico designed structural databases, molecular modeling studies and quantitative structure-activity relationship (QSAR) analyses in the development of novel rational P-gp inhibitors have also been mentioned." @default.
• W2010014978 created "2016-06-24" @default.
• W2010014978 creator A5059608180 @default.
• W2010014978 creator A5089815557 @default.
• W2010014978 date "2012-09-01" @default.
• W2010014978 modified "2023-10-04" @default.
• W2010014978 title "Overview of P-glycoprotein inhibitors: a rational outlook" @default.
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• W2010014978 cites W1807250678 @default.
• W2010014978 cites W1871508751 @default.
• W2010014978 cites W1964470226 @default.
• W2010014978 cites W1964909448 @default.
• W2010014978 cites W1967017848 @default.
• W2010014978 cites W1967386016 @default.
• W2010014978 cites W1968021518 @default.
• W2010014978 cites W1970631293 @default.
• W2010014978 cites W1974309806 @default.
• W2010014978 cites W1976569082 @default.
• W2010014978 cites W1981178961 @default.
• W2010014978 cites W1981376295 @default.
• W2010014978 cites W1983173409 @default.
• W2010014978 cites W1983544050 @default.
• W2010014978 cites W1985443358 @default.
• W2010014978 cites W1987792429 @default.
• W2010014978 cites W1998985130 @default.
• W2010014978 cites W2000933604 @default.
• W2010014978 cites W2001834121 @default.
• W2010014978 cites W2002374179 @default.
• W2010014978 cites W2002633786 @default.
• W2010014978 cites W2002892327 @default.
• W2010014978 cites W2004122590 @default.
• W2010014978 cites W2005673334 @default.
• W2010014978 cites W2013329423 @default.
• W2010014978 cites W2014013678 @default.
• W2010014978 cites W2014218134 @default.
• W2010014978 cites W2017144719 @default.
• W2010014978 cites W2018190618 @default.
• W2010014978 cites W2019346113 @default.
• W2010014978 cites W2024257431 @default.
• W2010014978 cites W2027277696 @default.
• W2010014978 cites W2028394719 @default.
• W2010014978 cites W2028533496 @default.
• W2010014978 cites W2035019909 @default.
• W2010014978 cites W2035064544 @default.
• W2010014978 cites W2036459378 @default.
• W2010014978 cites W2042066665 @default.
• W2010014978 cites W2043667393 @default.
• W2010014978 cites W2046826638 @default.
• W2010014978 cites W2047600655 @default.
• W2010014978 cites W2049147399 @default.
• W2010014978 cites W2051215695 @default.
• W2010014978 cites W2051773690 @default.
• W2010014978 cites W2052064334 @default.
• W2010014978 cites W2055274038 @default.
• W2010014978 cites W2055576047 @default.
• W2010014978 cites W2056165515 @default.
• W2010014978 cites W2058928933 @default.
• W2010014978 cites W2059303642 @default.
• W2010014978 cites W2059617501 @default.
• W2010014978 cites W2065068389 @default.
• W2010014978 cites W2067630917 @default.
• W2010014978 cites W2067983816 @default.
• W2010014978 cites W2068776830 @default.
• W2010014978 cites W2069907205 @default.
• W2010014978 cites W2071183486 @default.
• W2010014978 cites W2072812577 @default.
• W2010014978 cites W2074824346 @default.
• W2010014978 cites W2090841445 @default.
• W2010014978 cites W2091483354 @default.
• W2010014978 cites W2092357016 @default.
• W2010014978 cites W2094303590 @default.
• W2010014978 cites W2099482827 @default.
• W2010014978 cites W2105697161 @default.
• W2010014978 cites W2106483532 @default.
• W2010014978 cites W2109506936 @default.
• W2010014978 cites W2112390445 @default.
• W2010014978 cites W2115960763 @default.
• W2010014978 cites W2127379628 @default.
• W2010014978 cites W2129175180 @default.
• W2010014978 cites W2136860591 @default.
• W2010014978 cites W2138020718 @default.
• W2010014978 cites W2141087247 @default.
• W2010014978 cites W2166195582 @default.
• W2010014978 cites W2169536218 @default.
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• W2010014978 doi "https://doi.org/10.1590/s1984-82502012000300002" @default.
• W2010014978 hasPublicationYear "2012" @default.
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