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- W2010015376 abstract "Abstract Background Cardiac remodelling following myocardial infarction (MI) is a complex, dynamic process. There have been few longitudinal studies of these changes. Methods A 2-dimensional transthoracic echocardiography was performed on 20 rabbits, before and 1, 2, 4, 8, and 12 weeks after MI (n = 14) and twice for controls (n = 6). Chronic left ventricular (LV) infarct size was histologically characterized and correlated with mechanical function. A linear mixed model was used to analyze longitudinal and infarct size-related changes in LV end-systolic volume (ESV), end-diastolic volume (EDV), ejection fraction (EF), sphericity, circumferential strain, and wall motion score index. Results Mean LV infarct size was 28.9% ± 9.3%. After MI, rapid remodelling occurred in LVESV, LVEF, and sphericity for 2 weeks and LVEDV for 4 weeks, with slower changes afterwards. LV infarct size correlated with LVESV ( r = 0.76), LVEDV ( r = 0.71), and LVEF ( r = 0.69). Larger infarcts resulted in greater LVESV dilation ( P = 0.04) and faster LVEDV ( P 0.01), LVEF ( P 0.01), and sphericity ( P 0.01) remodelling. Apical global circumferential strain and wall motion score index increased for 1 week, then stabilized, regardless of infarct size, and apical global circumferential strain was correlated with apical infarction ( r = 0.58). Additionally, regional circumferential strain decreased in segments with severe (> 80%) infarction more quickly ( P P = 0.04) compared with segments with minor ( Conclusions The most dynamic remodelling of cardiac function in this model occurred during the first 4 weeks, stabilizing thereafter, with changes maintained up to 12 weeks. Infarct size affected both the early rate and long-term extent of mechanical remodelling." @default.
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- W2010015376 date "2012-03-01" @default.
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- W2010015376 title "Longitudinal Study of Cardiac Remodelling in Rabbits Following Infarction" @default.
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- W2010015376 doi "https://doi.org/10.1016/j.cjca.2011.11.003" @default.
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