FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010015557> ?p ?o ?g. }

• W2010015557 endingPage "11" @default.
• W2010015557 startingPage "1" @default.
• W2010015557 abstract "Mainstream cigarette smoke (CS) and wood smoke (WS) were compared in terms of their pulmonary CYP1A1 inducibility. The inducibility was assessed in pulmonary microsomes from rats exposed to freshly generated CS or WS and in rat lung explants treated with extracts of CS or WS total particulate matter (TPM). Mutagenicity in Salmonella typhimurium TA98 and TA100, an effect established for CS and WS in previous studies, was also examined as a test of the biological activity of the smoke samples in the present study. Pulmonary microsomal CYP1A1 activity (as measured by ethoxyresorufin O-deethylase), was induced 4.4-fold and 8.3-fold following exposure of rats to smoke from a single cigarette and three cigarettes, respectively, relative to the activity in control rats. The induction was paralleled by elevated CYP1A1 mRNA level (by northern blot analysis). WS, in contrast to CS, induced neither pulmonary CYP1A1 activity nor mRNA in exposed rats. CYP1A1 protein (by western blot analysis) was induced in cultured rat lung explants by extracts of CS TPM or by a high concentration (496 nM) of benzo[a]pyrene (B[a]P) but not by extracts of WS TPM or a low concentration (0.110 nM) of B[a]P. The induction by high B[a]P concentration was inhibited by extracts of CS or WS TPM, with the inhibition by extracts of WS TPM (75%) being greater than that by extracts of CS TPM (31%). Extracts of CS TPM were as mutagenic as extracts of WS TPM to Salmonella typhimurium TA98 but were more mutagenic than extracts of WS TPM to Salmonella typhimurium TA100. The results show that CS and WS are mutagenic but that WS differs from CS in its inability to induce pulmonary CYP1A1." @default.
• W2010015557 created "2016-06-24" @default.
• W2010015557 creator A5005021251 @default.
• W2010015557 creator A5014890619 @default.
• W2010015557 creator A5016271908 @default.
• W2010015557 creator A5017730279 @default.
• W2010015557 creator A5021360402 @default.
• W2010015557 creator A5026120117 @default.
• W2010015557 creator A5035662940 @default.
• W2010015557 creator A5040768148 @default.
• W2010015557 creator A5064573915 @default.
• W2010015557 date "2006-07-01" @default.
• W2010015557 modified "2023-09-29" @default.
• W2010015557 title "Differential inducibility of rat pulmonary CYP1A1 by cigarette smoke and wood smoke" @default.
• W2010015557 cites W1519277389 @default.
• W2010015557 cites W1775749144 @default.
• W2010015557 cites W1966456621 @default.
• W2010015557 cites W1968819739 @default.
• W2010015557 cites W1973406500 @default.
• W2010015557 cites W1976056213 @default.
• W2010015557 cites W1978370636 @default.
• W2010015557 cites W1981648925 @default.
• W2010015557 cites W1990871316 @default.
• W2010015557 cites W1994867734 @default.
• W2010015557 cites W2002301710 @default.
• W2010015557 cites W2004971707 @default.
• W2010015557 cites W2005156172 @default.
• W2010015557 cites W2012921569 @default.
• W2010015557 cites W2019408613 @default.
• W2010015557 cites W2024983422 @default.
• W2010015557 cites W2027548206 @default.
• W2010015557 cites W2032146039 @default.
• W2010015557 cites W2036315010 @default.
• W2010015557 cites W2042638186 @default.
• W2010015557 cites W2051989243 @default.
• W2010015557 cites W2056171781 @default.
• W2010015557 cites W2057734987 @default.
• W2010015557 cites W2059492191 @default.
• W2010015557 cites W2061816703 @default.
• W2010015557 cites W2062878170 @default.
• W2010015557 cites W2063019936 @default.
• W2010015557 cites W2064473976 @default.
• W2010015557 cites W2069593769 @default.
• W2010015557 cites W2081395866 @default.
• W2010015557 cites W2087425769 @default.
• W2010015557 cites W2100972980 @default.
• W2010015557 cites W2101026512 @default.
• W2010015557 cites W2102053457 @default.
• W2010015557 cites W2120867393 @default.
• W2010015557 cites W2125510702 @default.
• W2010015557 cites W2129667593 @default.
• W2010015557 cites W2131396896 @default.
• W2010015557 cites W2133968168 @default.
• W2010015557 cites W2141399461 @default.
• W2010015557 cites W2142522335 @default.
• W2010015557 cites W2147178029 @default.
• W2010015557 cites W2159369725 @default.
• W2010015557 cites W2160634992 @default.
• W2010015557 cites W2170423316 @default.
• W2010015557 cites W2233740420 @default.
• W2010015557 cites W2310587567 @default.
• W2010015557 cites W4242792033 @default.
• W2010015557 cites W4254364417 @default.
• W2010015557 cites W4294216491 @default.
• W2010015557 doi "https://doi.org/10.1016/j.mrgentox.2006.02.007" @default.
• W2010015557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16678472" @default.
• W2010015557 hasPublicationYear "2006" @default.
• W2010015557 type Work @default.
• W2010015557 sameAs 2010015557 @default.
• W2010015557 citedByCount "11" @default.
• W2010015557 countsByYear W20100155572013 @default.
• W2010015557 countsByYear W20100155572014 @default.
• W2010015557 countsByYear W20100155572015 @default.
• W2010015557 countsByYear W20100155572016 @default.
• W2010015557 countsByYear W20100155572022 @default.
• W2010015557 crossrefType "journal-article" @default.
• W2010015557 hasAuthorship W2010015557A5005021251 @default.
• W2010015557 hasAuthorship W2010015557A5014890619 @default.
• W2010015557 hasAuthorship W2010015557A5016271908 @default.
• W2010015557 hasAuthorship W2010015557A5017730279 @default.
• W2010015557 hasAuthorship W2010015557A5021360402 @default.
• W2010015557 hasAuthorship W2010015557A5026120117 @default.
• W2010015557 hasAuthorship W2010015557A5035662940 @default.
• W2010015557 hasAuthorship W2010015557A5040768148 @default.
• W2010015557 hasAuthorship W2010015557A5064573915 @default.
• W2010015557 hasConcept C104317684 @default.
• W2010015557 hasConcept C114246631 @default.
• W2010015557 hasConcept C129990765 @default.
• W2010015557 hasConcept C153911025 @default.
• W2010015557 hasConcept C178790620 @default.
• W2010015557 hasConcept C181199279 @default.
• W2010015557 hasConcept C185592680 @default.
• W2010015557 hasConcept C2776415932 @default.
• W2010015557 hasConcept C2777538855 @default.
• W2010015557 hasConcept C2778951431 @default.
• W2010015557 hasConcept C2781065037 @default.
• W2010015557 hasConcept C2993351451 @default.
• W2010015557 hasConcept C33070731 @default.

• next