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- W2010016099 abstract "The galectins comprise a family of 14 members of beta-galactoside-binding proteins, characterized by their affinity for beta-galactosides and by a conserved sequence in the carbohydrate recognition domain that bind to the carbohydrate portion of cell surface glycoproteins or glycolipids. Galectin-3, a 31kDa gene product, is a multifunctional oncogenic protein which regulates cell growth, cell adhesion, cell proliferation, angiogenesis, and apoptosis. Recent studies have revealed that galectin-3 demonstrates anti-apoptotic effects which contribute to cell survival in several types of cancer cells. Intracellular galectin-3 in particular, which contains the NWGR anti-death motif of the Bcl-2 family, inhibits cell apoptosis induced by chemotherapeutic agent such as cisplatin and etoposide in some types of cancer cells. We have also reported that nuclear export of phosphorylated galectin-3 regulates its anti-apoptotic activity in response to chemotherapeutic drugs. Here, we will describe the role of galectin-3 as an anti-apoptotic factor in response to chemotherapeutic drugs and will discuss recent data on its molecular mechanism that contribute to drug resistance. We suggest that targeting galectin-3 could improve the efficacy of anticancer drug chemotherapy in several types of cancer." @default.
- W2010016099 created "2016-06-24" @default.
- W2010016099 creator A5010903945 @default.
- W2010016099 creator A5036804010 @default.
- W2010016099 creator A5041522704 @default.
- W2010016099 date "2007-06-01" @default.
- W2010016099 modified "2023-10-11" @default.
- W2010016099 title "The role of galectin-3 in cancer drug resistance" @default.
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- W2010016099 doi "https://doi.org/10.1016/j.drup.2007.04.001" @default.
- W2010016099 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3626271" @default.
- W2010016099 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17544840" @default.
- W2010016099 hasPublicationYear "2007" @default.
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