Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010020469> ?p ?o ?g. }
- W2010020469 endingPage "e35467" @default.
- W2010020469 startingPage "e35467" @default.
- W2010020469 abstract "Acid sphingomyelinase (ASM) hydrolyses sphingomyelin and generates the lipid messenger ceramide, which mediates a variety of stress-related cellular processes. The pathological effects of dysregulated ASM activity are evident in several human diseases and indicate an important functional role for ASM regulation. We investigated alternative splicing as a possible mechanism for regulating cellular ASM activity.We identified three novel ASM splice variants in human cells, termed ASM-5, -6 and -7, which lack portions of the catalytic- and/or carboxy-terminal domains in comparison to full-length ASM-1. Differential expression patterns in primary blood cells indicated that ASM splicing might be subject to regulatory processes. The newly identified ASM splice variants were catalytically inactive in biochemical in vitro assays, but they decreased the relative cellular ceramide content in overexpression studies and exerted a dominant-negative effect on ASM activity in physiological cell models.These findings indicate that alternative splicing of ASM is of functional significance for the cellular stress response, possibly representing a mechanism for maintaining constant levels of cellular ASM enzyme activity." @default.
- W2010020469 created "2016-06-24" @default.
- W2010020469 creator A5004721027 @default.
- W2010020469 creator A5007229882 @default.
- W2010020469 creator A5011014804 @default.
- W2010020469 creator A5014084822 @default.
- W2010020469 creator A5017180868 @default.
- W2010020469 creator A5032805668 @default.
- W2010020469 creator A5033659234 @default.
- W2010020469 creator A5037138608 @default.
- W2010020469 creator A5041073789 @default.
- W2010020469 creator A5042391881 @default.
- W2010020469 creator A5049016107 @default.
- W2010020469 creator A5062076018 @default.
- W2010020469 creator A5067913949 @default.
- W2010020469 date "2012-04-27" @default.
- W2010020469 modified "2023-10-17" @default.
- W2010020469 title "Functional Implications of Novel Human Acid Sphingomyelinase Splice Variants" @default.
- W2010020469 cites W1501441539 @default.
- W2010020469 cites W1550942324 @default.
- W2010020469 cites W156960398 @default.
- W2010020469 cites W1660120640 @default.
- W2010020469 cites W1843461492 @default.
- W2010020469 cites W1921080167 @default.
- W2010020469 cites W1972847109 @default.
- W2010020469 cites W1980723388 @default.
- W2010020469 cites W1981239973 @default.
- W2010020469 cites W198273110 @default.
- W2010020469 cites W1985859001 @default.
- W2010020469 cites W1986234964 @default.
- W2010020469 cites W1995126002 @default.
- W2010020469 cites W2000404485 @default.
- W2010020469 cites W2004142844 @default.
- W2010020469 cites W2004740868 @default.
- W2010020469 cites W2007535223 @default.
- W2010020469 cites W2011181388 @default.
- W2010020469 cites W2023506303 @default.
- W2010020469 cites W2027648405 @default.
- W2010020469 cites W2028288720 @default.
- W2010020469 cites W2028365606 @default.
- W2010020469 cites W2029657851 @default.
- W2010020469 cites W2038617558 @default.
- W2010020469 cites W2039967350 @default.
- W2010020469 cites W2044351980 @default.
- W2010020469 cites W2049243778 @default.
- W2010020469 cites W2054087588 @default.
- W2010020469 cites W2065382050 @default.
- W2010020469 cites W2076355000 @default.
- W2010020469 cites W2092137773 @default.
- W2010020469 cites W2097347824 @default.
- W2010020469 cites W2100837269 @default.
- W2010020469 cites W2102711634 @default.
- W2010020469 cites W2102873939 @default.
- W2010020469 cites W2103931517 @default.
- W2010020469 cites W2123179956 @default.
- W2010020469 cites W2123283965 @default.
- W2010020469 cites W2124338566 @default.
- W2010020469 cites W2128171794 @default.
- W2010020469 cites W2135772628 @default.
- W2010020469 cites W2148165244 @default.
- W2010020469 cites W2154496845 @default.
- W2010020469 cites W2157308941 @default.
- W2010020469 cites W2168526937 @default.
- W2010020469 cites W2169193975 @default.
- W2010020469 cites W2169619725 @default.
- W2010020469 cites W2289395760 @default.
- W2010020469 doi "https://doi.org/10.1371/journal.pone.0035467" @default.
- W2010020469 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3338701" @default.
- W2010020469 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22558155" @default.
- W2010020469 hasPublicationYear "2012" @default.
- W2010020469 type Work @default.
- W2010020469 sameAs 2010020469 @default.
- W2010020469 citedByCount "28" @default.
- W2010020469 countsByYear W20100204692012 @default.
- W2010020469 countsByYear W20100204692013 @default.
- W2010020469 countsByYear W20100204692014 @default.
- W2010020469 countsByYear W20100204692015 @default.
- W2010020469 countsByYear W20100204692016 @default.
- W2010020469 countsByYear W20100204692017 @default.
- W2010020469 countsByYear W20100204692018 @default.
- W2010020469 countsByYear W20100204692019 @default.
- W2010020469 countsByYear W20100204692020 @default.
- W2010020469 countsByYear W20100204692021 @default.
- W2010020469 countsByYear W20100204692022 @default.
- W2010020469 countsByYear W20100204692023 @default.
- W2010020469 crossrefType "journal-article" @default.
- W2010020469 hasAuthorship W2010020469A5004721027 @default.
- W2010020469 hasAuthorship W2010020469A5007229882 @default.
- W2010020469 hasAuthorship W2010020469A5011014804 @default.
- W2010020469 hasAuthorship W2010020469A5014084822 @default.
- W2010020469 hasAuthorship W2010020469A5017180868 @default.
- W2010020469 hasAuthorship W2010020469A5032805668 @default.
- W2010020469 hasAuthorship W2010020469A5033659234 @default.
- W2010020469 hasAuthorship W2010020469A5037138608 @default.
- W2010020469 hasAuthorship W2010020469A5041073789 @default.
- W2010020469 hasAuthorship W2010020469A5042391881 @default.
- W2010020469 hasAuthorship W2010020469A5049016107 @default.
- W2010020469 hasAuthorship W2010020469A5062076018 @default.