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- W2010022018 abstract "Oxidative stress can cause DNA breaks which induce activation of the DNA nick sensor enzyme poly(ADP-ribose) polymerase-1 (PARP-1), part of the 17 member PARP enzyme family. PARP-1 modifies target proteins by attaching to them several NAD-derived ADP-ribose units forming poly(ADP-ribose) (PAR) polymers. PARylation controls many cellular processes while intense PARylation may also lead to cell death by various mechanisms. Here we summarize the modes of activation, inhibitors and modulators of PARP-1 and review the cellular functions regulated by the enzyme." @default.
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- W2010022018 date "2014-01-01" @default.
- W2010022018 modified "2023-10-18" @default.
- W2010022018 title "Inputs and outputs of poly(ADP-ribosyl)ation: Relevance to oxidative stress" @default.
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- W2010022018 doi "https://doi.org/10.1016/j.redox.2014.08.003" @default.
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