Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010025987> ?p ?o ?g. }
- W2010025987 endingPage "25" @default.
- W2010025987 startingPage "15" @default.
- W2010025987 abstract "Here, we report that siRNA transfection of β-adducin significantly disrupted the spectrin-based cytoskeleton and cytoskeletal arrangements of both β-adducin and PKCδ by substantially inhibiting the expression of β-adducin, spectrin and PKCδ proteins in differentiating keratinocytes. However, extracellular Ca2+ treatment blocked the inhibitory effects of the β-adducin siRNA. Ca2+ also prevented the significant down-regulation of two differentiation markers involucrin and K1/10 and the distinct up-regulation of proliferation marker K14 in β-adducin siRNA transfected keratinocytes. In addition, β-adducin knockdown resulted in a substantial reduction of epidermal growth factor receptor (EGFR), cadherin and β-catenin and enhanced phosphorylation of EGFR on tyrosine 1173 and Ca2+ prevented these changes. Furthermore, Ca2+ blocked the inhibitory effects of β-adducin siRNA on the expression of calmodulin, phosphorylated-calmodulin (P-CaM((Tyr138))) and myristoylated alanine-rich C-kinase substrate (MARCKS) in keratinocytes. Co-immunoprecipitation studies further revealed that calmodulin, not MARCKS, strongly interacted with EGFR, cadherin and β-catenin. Our data suggest that Ca2+ plays an important role in regulating the expression and function of β-adducin to sustain normal organization of the spectrin-based cytoskeleton and the differentiation properties in keratinocytes through the calmodulin/EGFR/cadherin signaling pathway." @default.
- W2010025987 created "2016-06-24" @default.
- W2010025987 creator A5042377027 @default.
- W2010025987 creator A5044685198 @default.
- W2010025987 creator A5058107287 @default.
- W2010025987 creator A5067364038 @default.
- W2010025987 creator A5083883398 @default.
- W2010025987 creator A5086310893 @default.
- W2010025987 date "2015-01-01" @default.
- W2010025987 modified "2023-10-16" @default.
- W2010025987 title "β-Adducin siRNA disruption of the spectrin-based cytoskeleton in differentiating keratinocytes prevented by calcium acting through calmodulin/epidermal growth factor receptor/cadherin pathway" @default.
- W2010025987 cites W1562144022 @default.
- W2010025987 cites W1567371960 @default.
- W2010025987 cites W1601691609 @default.
- W2010025987 cites W1964922513 @default.
- W2010025987 cites W1970287326 @default.
- W2010025987 cites W1973869185 @default.
- W2010025987 cites W1984947863 @default.
- W2010025987 cites W1987087186 @default.
- W2010025987 cites W1990639604 @default.
- W2010025987 cites W1992602954 @default.
- W2010025987 cites W1992827279 @default.
- W2010025987 cites W1995249103 @default.
- W2010025987 cites W1999863087 @default.
- W2010025987 cites W2007374663 @default.
- W2010025987 cites W2011874472 @default.
- W2010025987 cites W2012802266 @default.
- W2010025987 cites W2014954303 @default.
- W2010025987 cites W2036890547 @default.
- W2010025987 cites W2037299149 @default.
- W2010025987 cites W2037510822 @default.
- W2010025987 cites W2041903101 @default.
- W2010025987 cites W2043103226 @default.
- W2010025987 cites W2052366943 @default.
- W2010025987 cites W2053718310 @default.
- W2010025987 cites W2064021058 @default.
- W2010025987 cites W2065247382 @default.
- W2010025987 cites W2068721549 @default.
- W2010025987 cites W2071812166 @default.
- W2010025987 cites W2072779149 @default.
- W2010025987 cites W2074645214 @default.
- W2010025987 cites W2089765713 @default.
- W2010025987 cites W2096206713 @default.
- W2010025987 cites W2097492158 @default.
- W2010025987 cites W2117256163 @default.
- W2010025987 cites W2120030068 @default.
- W2010025987 cites W2120868462 @default.
- W2010025987 cites W2133034511 @default.
- W2010025987 cites W2146402949 @default.
- W2010025987 cites W2146894808 @default.
- W2010025987 cites W2155467139 @default.
- W2010025987 cites W2162873248 @default.
- W2010025987 cites W2165178639 @default.
- W2010025987 cites W85083754 @default.
- W2010025987 cites W2031086462 @default.
- W2010025987 doi "https://doi.org/10.1016/j.cellsig.2014.10.001" @default.
- W2010025987 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25305142" @default.
- W2010025987 hasPublicationYear "2015" @default.
- W2010025987 type Work @default.
- W2010025987 sameAs 2010025987 @default.
- W2010025987 citedByCount "12" @default.
- W2010025987 countsByYear W20100259872015 @default.
- W2010025987 countsByYear W20100259872017 @default.
- W2010025987 countsByYear W20100259872018 @default.
- W2010025987 countsByYear W20100259872019 @default.
- W2010025987 countsByYear W20100259872020 @default.
- W2010025987 countsByYear W20100259872022 @default.
- W2010025987 countsByYear W20100259872023 @default.
- W2010025987 crossrefType "journal-article" @default.
- W2010025987 hasAuthorship W2010025987A5042377027 @default.
- W2010025987 hasAuthorship W2010025987A5044685198 @default.
- W2010025987 hasAuthorship W2010025987A5058107287 @default.
- W2010025987 hasAuthorship W2010025987A5067364038 @default.
- W2010025987 hasAuthorship W2010025987A5083883398 @default.
- W2010025987 hasAuthorship W2010025987A5086310893 @default.
- W2010025987 hasConcept C11960822 @default.
- W2010025987 hasConcept C142669718 @default.
- W2010025987 hasConcept C1491633281 @default.
- W2010025987 hasConcept C153911025 @default.
- W2010025987 hasConcept C170493617 @default.
- W2010025987 hasConcept C181199279 @default.
- W2010025987 hasConcept C195794163 @default.
- W2010025987 hasConcept C2779438470 @default.
- W2010025987 hasConcept C2780780085 @default.
- W2010025987 hasConcept C29688787 @default.
- W2010025987 hasConcept C50244902 @default.
- W2010025987 hasConcept C54009773 @default.
- W2010025987 hasConcept C54355233 @default.
- W2010025987 hasConcept C55493867 @default.
- W2010025987 hasConcept C62478195 @default.
- W2010025987 hasConcept C71829478 @default.
- W2010025987 hasConcept C81885089 @default.
- W2010025987 hasConcept C86803240 @default.
- W2010025987 hasConcept C95444343 @default.
- W2010025987 hasConceptScore W2010025987C11960822 @default.
- W2010025987 hasConceptScore W2010025987C142669718 @default.
- W2010025987 hasConceptScore W2010025987C1491633281 @default.
- W2010025987 hasConceptScore W2010025987C153911025 @default.