Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010026997> ?p ?o ?g. }
- W2010026997 endingPage "e42976" @default.
- W2010026997 startingPage "e42976" @default.
- W2010026997 abstract "Breast cancer metastasis suppressor 1 (BRMS1) was originally identified as an active metastasis suppressor in human breast cancer. Loss of BRMS1 expression correlates with tumor progression, and BRMS1 suppresses several steps required for tumor metastasis. However, the role of BRMS1 in hepatocellular carcinoma (HCC) remains elusive. In this study, we found that the expression level of BRMS1 was significantly down-regulated in HCC tissues. Expression of BRMS1 in SK-Hep1 cells did not affect cell growth under normal culture conditions, but sensitized cells to apoptosis induced by serum deprivation or anoikis. Consistently, knockdown of endogenous BRMS1 expression in Hep3B cells suppressed cell apoptosis. We identified that BRMS1 suppresses osteopontin (OPN) expression in HCC cells and that there is a negative correlation between BRMS1 and OPN mRNA expression in HCC tissues. Moreover, knockdown of endogenous OPN expression reversed the anti-apoptosis effect achieved by knockdown of BRMS1. Taken together, our results show that BRMS1 sensitizes HCC cells to apoptosis through suppressing OPN expression, suggesting a potential role of BRMS1 in regulating HCC apoptosis and metastasis." @default.
- W2010026997 created "2016-06-24" @default.
- W2010026997 creator A5007769872 @default.
- W2010026997 creator A5014852093 @default.
- W2010026997 creator A5016853432 @default.
- W2010026997 creator A5041346764 @default.
- W2010026997 creator A5048734861 @default.
- W2010026997 creator A5049986425 @default.
- W2010026997 creator A5054774521 @default.
- W2010026997 creator A5056661622 @default.
- W2010026997 creator A5060176078 @default.
- W2010026997 creator A5064146611 @default.
- W2010026997 creator A5065869973 @default.
- W2010026997 creator A5080470862 @default.
- W2010026997 creator A5088677379 @default.
- W2010026997 date "2012-08-21" @default.
- W2010026997 modified "2023-09-25" @default.
- W2010026997 title "Breast Cancer Metastasis Suppressor 1 Regulates Hepatocellular Carcinoma Cell Apoptosis via Suppressing Osteopontin Expression" @default.
- W2010026997 cites W1510237891 @default.
- W2010026997 cites W1580407590 @default.
- W2010026997 cites W1591304277 @default.
- W2010026997 cites W1603067300 @default.
- W2010026997 cites W1798283087 @default.
- W2010026997 cites W1807491301 @default.
- W2010026997 cites W1827917779 @default.
- W2010026997 cites W1929541719 @default.
- W2010026997 cites W1967739793 @default.
- W2010026997 cites W1969699638 @default.
- W2010026997 cites W1969909442 @default.
- W2010026997 cites W1972162901 @default.
- W2010026997 cites W1977461339 @default.
- W2010026997 cites W1977630546 @default.
- W2010026997 cites W1979206942 @default.
- W2010026997 cites W1990511361 @default.
- W2010026997 cites W1993690997 @default.
- W2010026997 cites W1994198080 @default.
- W2010026997 cites W1995903946 @default.
- W2010026997 cites W2003729329 @default.
- W2010026997 cites W2005307774 @default.
- W2010026997 cites W2007601283 @default.
- W2010026997 cites W2014783572 @default.
- W2010026997 cites W2024073746 @default.
- W2010026997 cites W2026546029 @default.
- W2010026997 cites W2026770310 @default.
- W2010026997 cites W2032782941 @default.
- W2010026997 cites W2033919910 @default.
- W2010026997 cites W2036362283 @default.
- W2010026997 cites W2037145474 @default.
- W2010026997 cites W2037986858 @default.
- W2010026997 cites W2038414372 @default.
- W2010026997 cites W2042583579 @default.
- W2010026997 cites W2044325868 @default.
- W2010026997 cites W2045796964 @default.
- W2010026997 cites W2048854681 @default.
- W2010026997 cites W2051321252 @default.
- W2010026997 cites W2057774208 @default.
- W2010026997 cites W2081315229 @default.
- W2010026997 cites W2083113175 @default.
- W2010026997 cites W2086549514 @default.
- W2010026997 cites W2086887428 @default.
- W2010026997 cites W2089778459 @default.
- W2010026997 cites W2093921289 @default.
- W2010026997 cites W2099236110 @default.
- W2010026997 cites W2099939399 @default.
- W2010026997 cites W2108409152 @default.
- W2010026997 cites W2108722121 @default.
- W2010026997 cites W2118936905 @default.
- W2010026997 cites W2123287557 @default.
- W2010026997 cites W2123303768 @default.
- W2010026997 cites W2123306590 @default.
- W2010026997 cites W2123808188 @default.
- W2010026997 cites W2124133814 @default.
- W2010026997 cites W2137022580 @default.
- W2010026997 cites W2138863456 @default.
- W2010026997 cites W2139146830 @default.
- W2010026997 cites W2141283414 @default.
- W2010026997 cites W2151334198 @default.
- W2010026997 cites W2153397671 @default.
- W2010026997 cites W2157383773 @default.
- W2010026997 cites W2159276982 @default.
- W2010026997 cites W2169431719 @default.
- W2010026997 cites W2395302515 @default.
- W2010026997 cites W326741768 @default.
- W2010026997 doi "https://doi.org/10.1371/journal.pone.0042976" @default.
- W2010026997 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3424258" @default.
- W2010026997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22927944" @default.
- W2010026997 hasPublicationYear "2012" @default.
- W2010026997 type Work @default.
- W2010026997 sameAs 2010026997 @default.
- W2010026997 citedByCount "29" @default.
- W2010026997 countsByYear W20100269972013 @default.
- W2010026997 countsByYear W20100269972014 @default.
- W2010026997 countsByYear W20100269972015 @default.
- W2010026997 countsByYear W20100269972016 @default.
- W2010026997 countsByYear W20100269972017 @default.
- W2010026997 countsByYear W20100269972018 @default.
- W2010026997 countsByYear W20100269972019 @default.
- W2010026997 countsByYear W20100269972021 @default.