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- W2010028757 abstract "The central mesencephalic reticular formation (cMRF) likely plays a role in gaze control, as cMRF neurons receive tectal input and provide a bilateral projection back to the superior colliculus (SC). We examined the important question of whether this feedback is excitatory or inhibitory. Biotinylated dextran amine (BDA) was injected into the cMRF of M. fascicularis monkeys to anterogradely label reticulotectal terminals and retrogradely label tectoreticular neurons. BDA labeled profiles in the ipsi- and contralateral intermediate gray layer (SGI) were examined electron microscopically. Postembedding GABA immunochemistry was used to identify putative inhibitory profiles. Nearly all (94.7%) of the ipsilateral BDA labeled terminals were GABA positive, but profiles postsynaptic to these labeled terminals were exclusively GABA negative. In addition, BDA labeled terminals were observed to contact BDA labeled dendrites, indicating the presence of a monosynaptic feedback loop connecting the cMRF and ipsilateral SC. In contrast, within the contralateral SGI, half of the BDA labeled terminals were GABA positive, while more than a third were GABA negative. All the postsynaptic profiles were GABA negative. These results indicate the cMRF provides inhibitory feedback to the ipsilateral side of the SC, but it has more complex effects on the contralateral side. The ipsilateral projection may help tune the winner-take-all mechanism that produces a unified saccade signal, while the contralateral projections may contribute to the coordination of activity between the two colliculi." @default.
- W2010028757 created "2016-06-24" @default.
- W2010028757 creator A5001238742 @default.
- W2010028757 creator A5060695289 @default.
- W2010028757 creator A5076845406 @default.
- W2010028757 date "2009-11-26" @default.
- W2010028757 modified "2023-10-06" @default.
- W2010028757 title "The macaque midbrain reticular formation sends side-specific feedback to the superior colliculus" @default.
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- W2010028757 doi "https://doi.org/10.1007/s00221-009-2090-0" @default.
- W2010028757 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2840059" @default.
- W2010028757 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19940983" @default.
- W2010028757 hasPublicationYear "2009" @default.
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