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- W2010032819 abstract "For patients with most types of solid tumors, metastases drive the morbidity and mortality of their disease. For patients with osteosarcoma this is particularly true, with metastases that occur almost exclusively within the lung. We set out to identify the factors that facilitate growth of osteosarcoma specifically within the lung environment. To do this, we identified a set of candidate genes and tested them for reliably enriched levels of expression in metastatic lesions relative to primary tumors in the same patients. IL-6 and IL-8 are among the most reliably enriched genes in the metastatic lesions. Osteosarcoma cell lines that express high-levels of IL-6 and IL-8 not only respond to these signals in an autocrine manner, but form lung metastases much more readily than cell lines with low IL-6 and IL-8 expression in mouse xenograft models. IL-6 and IL-8 drive chemokinesis, directional migration, and invasive activity in osteosarcoma cells independent of the degree to which they express these cytokines. Blocking IL-6 and IL-8 signals reduces the metastatic efficiency of osteosarcoma cells. These data suggest that IL-6 and IL-8 play a central role in the mechanisms that account for lung tropism in osteosarcoma and provide attractive targets for therapies intended to prevent metastasis in order to improve outcomes in patients with osteosarcoma. Citation Format: Ryan D. Roberts, Hemant K. Bid, Doris Phelps, Brett W. Hendrickson, Hakan Cam, Peter J. Houghton. Autocrine and paracrine IL-6 and IL-8 drive osteosarcoma metastasis. [abstract]. In: Proceedings of the AACR Special Conference on Pediatric Cancer at the Crossroads: Translating Discovery into Improved Outcomes; Nov 3-6, 2013; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2013;74(20 Suppl):Abstract nr A45." @default.
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- W2010032819 date "2014-10-09" @default.
- W2010032819 modified "2023-09-25" @default.
- W2010032819 title "Abstract A45: Autocrine and paracrine IL-6 and IL-8 drive osteosarcoma metastasis" @default.
- W2010032819 doi "https://doi.org/10.1158/1538-7445.pedcan-a45" @default.
- W2010032819 hasPublicationYear "2014" @default.
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