FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010033523> ?p ?o ?g. }

• W2010033523 endingPage "283" @default.
• W2010033523 startingPage "277" @default.
• W2010033523 abstract "The ubiquitin+proteasome system (UPS) is a highly complex network that maintains protein homeostasis and cell viability through the selective turnover of targeted substrates. The proteasome serves as the catalytic core of the UPS to recognize and execute the coordinated and efficient removal of ubiquitinated proteins. Pharmacologic inhibitors that exploit the pivotal role of the proteasome in cellular metabolism promote tumor cytotoxicity and have yielded durable clinical responses that dramatically improve patient survival. Success of the proteasome inhibitor (PI) bortezomib in the treatment of the hematologic malignancy multiple myeloma (MM) has emerged as the standard-of-care and catapulted the UPS into a position of prominence as a model system in cancer biology and drug development. However, expansion of PIs in the treatment of the more complex solid tumors has been less successful. While clinical evaluation of second-generation PIs progresses, other potential sites of therapeutic intervention within the UPS continue to emerge, such as the non-proteolytic activities associated with the proteasome and the rapidly expanding number of Ub-binding proteins. Molecular-genetic approaches to further unravel the complexity of the UPS will advance its utilization as a platform for the development of novel, mechanism-based anticancer strategies." @default.
• W2010033523 created "2016-06-24" @default.
• W2010033523 creator A5035898667 @default.
• W2010033523 creator A5054506083 @default.
• W2010033523 date "2012-07-01" @default.
• W2010033523 modified "2023-09-25" @default.
• W2010033523 title "Targeting the Ubiquitin+Proteasome System in Solid Tumors" @default.
• W2010033523 cites W1504533062 @default.
• W2010033523 cites W1528984990 @default.
• W2010033523 cites W1551702901 @default.
• W2010033523 cites W1590553747 @default.
• W2010033523 cites W1964227266 @default.
• W2010033523 cites W1974010669 @default.
• W2010033523 cites W1974577865 @default.
• W2010033523 cites W1977733856 @default.
• W2010033523 cites W1979947947 @default.
• W2010033523 cites W1980471295 @default.
• W2010033523 cites W1982273478 @default.
• W2010033523 cites W1987583882 @default.
• W2010033523 cites W1993246239 @default.
• W2010033523 cites W1995596496 @default.
• W2010033523 cites W1995786747 @default.
• W2010033523 cites W1998626286 @default.
• W2010033523 cites W2009058293 @default.
• W2010033523 cites W2012296420 @default.
• W2010033523 cites W2018674722 @default.
• W2010033523 cites W2027250628 @default.
• W2010033523 cites W2033394004 @default.
• W2010033523 cites W2039374629 @default.
• W2010033523 cites W2047455709 @default.
• W2010033523 cites W2051458654 @default.
• W2010033523 cites W2067301662 @default.
• W2010033523 cites W2069992059 @default.
• W2010033523 cites W2076194625 @default.
• W2010033523 cites W2078766933 @default.
• W2010033523 cites W2090926709 @default.
• W2010033523 cites W2096646435 @default.
• W2010033523 cites W2097164847 @default.
• W2010033523 cites W2107997405 @default.
• W2010033523 cites W2109034822 @default.
• W2010033523 cites W2121398618 @default.
• W2010033523 cites W2121577209 @default.
• W2010033523 cites W2126267349 @default.
• W2010033523 cites W2126467039 @default.
• W2010033523 cites W2134102124 @default.
• W2010033523 cites W2139577310 @default.
• W2010033523 cites W2140182533 @default.
• W2010033523 cites W2155033951 @default.
• W2010033523 cites W2155468968 @default.
• W2010033523 cites W2156440292 @default.
• W2010033523 cites W2156813481 @default.
• W2010033523 cites W2163700260 @default.
• W2010033523 cites W2166761147 @default.
• W2010033523 cites W2168458127 @default.
• W2010033523 cites W2171155178 @default.
• W2010033523 cites W2244632544 @default.
• W2010033523 cites W2411167891 @default.
• W2010033523 cites W2526922410 @default.
• W2010033523 cites W2589528623 @default.
• W2010033523 doi "https://doi.org/10.1053/j.seminhematol.2012.04.002" @default.
• W2010033523 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22726552" @default.
• W2010033523 hasPublicationYear "2012" @default.
• W2010033523 type Work @default.
• W2010033523 sameAs 2010033523 @default.
• W2010033523 citedByCount "31" @default.
• W2010033523 countsByYear W20100335232012 @default.
• W2010033523 countsByYear W20100335232013 @default.
• W2010033523 countsByYear W20100335232014 @default.
• W2010033523 countsByYear W20100335232015 @default.
• W2010033523 countsByYear W20100335232016 @default.
• W2010033523 countsByYear W20100335232018 @default.
• W2010033523 countsByYear W20100335232019 @default.
• W2010033523 countsByYear W20100335232020 @default.
• W2010033523 countsByYear W20100335232021 @default.
• W2010033523 countsByYear W20100335232022 @default.
• W2010033523 countsByYear W20100335232023 @default.
• W2010033523 crossrefType "journal-article" @default.
• W2010033523 hasAuthorship W2010033523A5035898667 @default.
• W2010033523 hasAuthorship W2010033523A5054506083 @default.
• W2010033523 hasConcept C104317684 @default.
• W2010033523 hasConcept C111472728 @default.
• W2010033523 hasConcept C126322002 @default.
• W2010033523 hasConcept C138885662 @default.
• W2010033523 hasConcept C203014093 @default.
• W2010033523 hasConcept C25602115 @default.
• W2010033523 hasConcept C27740335 @default.
• W2010033523 hasConcept C2776364478 @default.
• W2010033523 hasConcept C2777478702 @default.
• W2010033523 hasConcept C2778367456 @default.
• W2010033523 hasConcept C2909984355 @default.
• W2010033523 hasConcept C502942594 @default.
• W2010033523 hasConcept C55493867 @default.
• W2010033523 hasConcept C70721500 @default.
• W2010033523 hasConcept C71924100 @default.
• W2010033523 hasConcept C86803240 @default.
• W2010033523 hasConcept C89611455 @default.
• W2010033523 hasConcept C95444343 @default.
• W2010033523 hasConceptScore W2010033523C104317684 @default.

• next