FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010033770> ?p ?o ?g. }

• W2010033770 endingPage "e1002863" @default.
• W2010033770 startingPage "e1002863" @default.
• W2010033770 abstract "Many cells in a developing embryo, including neurons and their axons and growth cones, must integrate multiple guidance cues to undergo directed growth and migration. The UNC-6/netrin, SLT-1/slit, and VAB-2/Ephrin guidance cues, and their receptors, UNC-40/DCC, SAX-3/Robo, and VAB-1/Eph, are known to be major regulators of cellular growth and migration. One important area of research is identifying the molecules that interpret this guidance information downstream of the guidance receptors to reorganize the actin cytoskeleton. However, how guidance cues regulate the actin cytoskeleton is not well understood. We report here that UNC-40/DCC, SAX-3/Robo, and VAB-1/Eph differentially regulate the abundance and subcellular localization of the WAVE/SCAR actin nucleation complex and its activator, Rac1/CED-10, in the Caenorhabditis elegans embryonic epidermis. Loss of any of these three pathways results in embryos that fail embryonic morphogenesis. Similar defects in epidermal enclosure have been observed when CED-10/Rac1 or the WAVE/SCAR actin nucleation complex are missing during embryonic development in C. elegans. Genetic and molecular experiments demonstrate that in fact, these three axonal guidance proteins differentially regulate the levels and membrane enrichment of the WAVE/SCAR complex and its activator, Rac1/CED-10, in the epidermis. Live imaging of filamentous actin (F-actin) in embryos developing in the absence of individual guidance receptors shows that high levels of F-actin are not essential for polarized cell migrations, but that properly polarized distribution of F-actin is essential. These results suggest that proper membrane recruitment and activation of CED-10/Rac1 and of WAVE/SCAR by signals at the plasma membrane result in polarized F-actin that permits directed movements and suggest how multiple guidance cues can result in distinct changes in actin nucleation during morphogenesis." @default.
• W2010033770 created "2016-06-24" @default.
• W2010033770 creator A5015776014 @default.
• W2010033770 creator A5017724492 @default.
• W2010033770 creator A5039686773 @default.
• W2010033770 creator A5050387048 @default.
• W2010033770 creator A5063735663 @default.
• W2010033770 date "2012-08-02" @default.
• W2010033770 modified "2023-10-17" @default.
• W2010033770 title "UNC-40/DCC, SAX-3/Robo, and VAB-1/Eph Polarize F-Actin during Embryonic Morphogenesis by Regulating the WAVE/SCAR Actin Nucleation Complex" @default.
• W2010033770 cites W1533988685 @default.
• W2010033770 cites W1603342850 @default.
• W2010033770 cites W1924646174 @default.
• W2010033770 cites W1964359283 @default.
• W2010033770 cites W1964816418 @default.
• W2010033770 cites W1976179891 @default.
• W2010033770 cites W1977572593 @default.
• W2010033770 cites W1985617800 @default.
• W2010033770 cites W1994044440 @default.
• W2010033770 cites W1997228602 @default.
• W2010033770 cites W1998604466 @default.
• W2010033770 cites W2000814069 @default.
• W2010033770 cites W2017337617 @default.
• W2010033770 cites W2023354623 @default.
• W2010033770 cites W2027919192 @default.
• W2010033770 cites W2032419047 @default.
• W2010033770 cites W2035455156 @default.
• W2010033770 cites W2036473961 @default.
• W2010033770 cites W2047923314 @default.
• W2010033770 cites W2052711805 @default.
• W2010033770 cites W2057506802 @default.
• W2010033770 cites W2060328732 @default.
• W2010033770 cites W2066953183 @default.
• W2010033770 cites W2078801891 @default.
• W2010033770 cites W2079595896 @default.
• W2010033770 cites W2088345383 @default.
• W2010033770 cites W2090194270 @default.
• W2010033770 cites W2090865074 @default.
• W2010033770 cites W2098743384 @default.
• W2010033770 cites W2104201613 @default.
• W2010033770 cites W2104789070 @default.
• W2010033770 cites W2105030314 @default.
• W2010033770 cites W2105622034 @default.
• W2010033770 cites W2109016514 @default.
• W2010033770 cites W2113936637 @default.
• W2010033770 cites W2120879594 @default.
• W2010033770 cites W2121764727 @default.
• W2010033770 cites W2124440591 @default.
• W2010033770 cites W2125983595 @default.
• W2010033770 cites W2130269585 @default.
• W2010033770 cites W2134487528 @default.
• W2010033770 cites W2145294610 @default.
• W2010033770 cites W2146597600 @default.
• W2010033770 cites W2150019612 @default.
• W2010033770 cites W2151256777 @default.
• W2010033770 cites W2160025503 @default.
• W2010033770 cites W2161950735 @default.
• W2010033770 cites W2164591040 @default.
• W2010033770 cites W2166130624 @default.
• W2010033770 cites W2170872197 @default.
• W2010033770 cites W2171785936 @default.
• W2010033770 doi "https://doi.org/10.1371/journal.pgen.1002863" @default.
• W2010033770 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3410845" @default.
• W2010033770 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22876199" @default.
• W2010033770 hasPublicationYear "2012" @default.
• W2010033770 type Work @default.
• W2010033770 sameAs 2010033770 @default.
• W2010033770 citedByCount "49" @default.
• W2010033770 countsByYear W20100337702012 @default.
• W2010033770 countsByYear W20100337702013 @default.
• W2010033770 countsByYear W20100337702014 @default.
• W2010033770 countsByYear W20100337702015 @default.
• W2010033770 countsByYear W20100337702016 @default.
• W2010033770 countsByYear W20100337702017 @default.
• W2010033770 countsByYear W20100337702018 @default.
• W2010033770 countsByYear W20100337702019 @default.
• W2010033770 countsByYear W20100337702020 @default.
• W2010033770 countsByYear W20100337702021 @default.
• W2010033770 countsByYear W20100337702022 @default.
• W2010033770 countsByYear W20100337702023 @default.
• W2010033770 crossrefType "journal-article" @default.
• W2010033770 hasAuthorship W2010033770A5015776014 @default.
• W2010033770 hasAuthorship W2010033770A5017724492 @default.
• W2010033770 hasAuthorship W2010033770A5039686773 @default.
• W2010033770 hasAuthorship W2010033770A5050387048 @default.
• W2010033770 hasAuthorship W2010033770A5063735663 @default.
• W2010033770 hasBestOaLocation W20100337701 @default.
• W2010033770 hasConcept C101544691 @default.
• W2010033770 hasConcept C104317684 @default.
• W2010033770 hasConcept C125705527 @default.
• W2010033770 hasConcept C127955056 @default.
• W2010033770 hasConcept C142669718 @default.
• W2010033770 hasConcept C145103041 @default.
• W2010033770 hasConcept C1491633281 @default.
• W2010033770 hasConcept C151000934 @default.
• W2010033770 hasConcept C170286479 @default.
• W2010033770 hasConcept C19331615 @default.
• W2010033770 hasConcept C2779530196 @default.

• next