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- W2010039139 abstract "We have determined that synaptic vesicles contain a vesicle-specific keratan sulfate integral membrane proteoglycan. This is a major proteoglycan in electric organ synaptic vesicles. It exists in two forms on sodium dodecyl sulfate-polyacrylamide gel electrophoresis, i.e., the L form, which migrates like a protein with an M(r) of 100,000, and the H form, with a lower mobility that migrates with an M(r) of approximately 250,000. Both forms contain SV2, an epitope located on the cytoplasmic side of the vesicle membrane. In addition to electric organ, we have analyzed the SV2 proteoglycan in vesicle fractions from two other sources, electric fish brain and rat brain. Both the H and L forms of SV2 are present in these vesicles and all are keratan sulfate proteoglycans. Unlike previously studied synaptic vesicle proteins, this proteoglycan contains a marker specific for a single group of neurons. This marker is an antigenically unique keratan sulfate side chain that is specific for the cells innervating the electric organ; it is not found on the synaptic vesicle keratan sulfate proteoglycan in other neurons of the electric fish brain." @default.
- W2010039139 created "2016-06-24" @default.
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- W2010039139 date "1993-07-01" @default.
- W2010039139 modified "2023-10-12" @default.
- W2010039139 title "The SV2 Protein of Synaptic Vesicles Is a Keratan Sulfate Proteoglycan" @default.
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- W2010039139 doi "https://doi.org/10.1111/j.1471-4159.1993.tb03535.x" @default.
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