Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010043835> ?p ?o ?g. }
- W2010043835 endingPage "783" @default.
- W2010043835 startingPage "768" @default.
- W2010043835 abstract "Inhibition of apoptotic response of host cells during an early phase of infection is a strategy used by many enteroinvasive bacterial pathogens to enhance their survival. Here, we report the identification of a soluble form of the pilus protein FimA from the culture supernatants of E. coli K1, Salmonella, and Shigella that can potently inhibit Bax-mediated release of cytochrome c from isolated mitochondria. Similar to the infected cells, HCT116 cells stably expressing FimA display a delay in the integration of Bax into outer mitochondrial membrane induced by apoptotic stimuli. FimA targets to mitochondria through binding to VDAC1, which is a prerequisite step for E. coli K1 to render the short-term blockade of apoptotic death in the host cells. Interestingly, FimA strengthens the VDAC1-hexokinase interaction and prevents dissociation of hexokinase from VDAC1 triggered by apoptotic stimuli. Together, these data thus reveal a paradigm of antiapoptosis mechanism undertaken by the enteroinvasive bacteria." @default.
- W2010043835 created "2016-06-24" @default.
- W2010043835 creator A5028853436 @default.
- W2010043835 creator A5029354259 @default.
- W2010043835 creator A5042702040 @default.
- W2010043835 creator A5063329257 @default.
- W2010043835 creator A5064608982 @default.
- W2010043835 creator A5066807844 @default.
- W2010043835 date "2010-03-01" @default.
- W2010043835 modified "2023-10-18" @default.
- W2010043835 title "A Soluble Form of the Pilus Protein FimA Targets the VDAC-Hexokinase Complex at Mitochondria to Suppress Host Cell Apoptosis" @default.
- W2010043835 cites W1607777232 @default.
- W2010043835 cites W1644794975 @default.
- W2010043835 cites W1793304642 @default.
- W2010043835 cites W1961727790 @default.
- W2010043835 cites W1964483580 @default.
- W2010043835 cites W1965320056 @default.
- W2010043835 cites W1975607775 @default.
- W2010043835 cites W1977258127 @default.
- W2010043835 cites W1986147894 @default.
- W2010043835 cites W1987226377 @default.
- W2010043835 cites W1987806865 @default.
- W2010043835 cites W1988917342 @default.
- W2010043835 cites W1992074619 @default.
- W2010043835 cites W1994186363 @default.
- W2010043835 cites W1994972720 @default.
- W2010043835 cites W2002919668 @default.
- W2010043835 cites W2003388311 @default.
- W2010043835 cites W2008376982 @default.
- W2010043835 cites W2022803736 @default.
- W2010043835 cites W2025291080 @default.
- W2010043835 cites W2026555011 @default.
- W2010043835 cites W2028680026 @default.
- W2010043835 cites W2028900979 @default.
- W2010043835 cites W2033873142 @default.
- W2010043835 cites W2035295886 @default.
- W2010043835 cites W2038469013 @default.
- W2010043835 cites W2043090124 @default.
- W2010043835 cites W2043697833 @default.
- W2010043835 cites W2054645758 @default.
- W2010043835 cites W2056117178 @default.
- W2010043835 cites W2057257618 @default.
- W2010043835 cites W2064325401 @default.
- W2010043835 cites W2064449011 @default.
- W2010043835 cites W2076796449 @default.
- W2010043835 cites W2087601381 @default.
- W2010043835 cites W2094052642 @default.
- W2010043835 cites W2094061196 @default.
- W2010043835 cites W2100262552 @default.
- W2010043835 cites W2102584757 @default.
- W2010043835 cites W2107580100 @default.
- W2010043835 cites W2112334754 @default.
- W2010043835 cites W2124086843 @default.
- W2010043835 cites W2125618705 @default.
- W2010043835 cites W2128368215 @default.
- W2010043835 cites W2131952786 @default.
- W2010043835 cites W2134087185 @default.
- W2010043835 cites W2134985843 @default.
- W2010043835 cites W2136269288 @default.
- W2010043835 cites W2137603320 @default.
- W2010043835 cites W2141937928 @default.
- W2010043835 cites W2144569256 @default.
- W2010043835 cites W2150315067 @default.
- W2010043835 cites W2156943914 @default.
- W2010043835 cites W2163032286 @default.
- W2010043835 cites W2321985754 @default.
- W2010043835 doi "https://doi.org/10.1016/j.molcel.2010.02.015" @default.
- W2010043835 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20347420" @default.
- W2010043835 hasPublicationYear "2010" @default.
- W2010043835 type Work @default.
- W2010043835 sameAs 2010043835 @default.
- W2010043835 citedByCount "43" @default.
- W2010043835 countsByYear W20100438352012 @default.
- W2010043835 countsByYear W20100438352014 @default.
- W2010043835 countsByYear W20100438352015 @default.
- W2010043835 countsByYear W20100438352016 @default.
- W2010043835 countsByYear W20100438352017 @default.
- W2010043835 countsByYear W20100438352018 @default.
- W2010043835 countsByYear W20100438352019 @default.
- W2010043835 countsByYear W20100438352020 @default.
- W2010043835 countsByYear W20100438352021 @default.
- W2010043835 countsByYear W20100438352022 @default.
- W2010043835 countsByYear W20100438352023 @default.
- W2010043835 crossrefType "journal-article" @default.
- W2010043835 hasAuthorship W2010043835A5028853436 @default.
- W2010043835 hasAuthorship W2010043835A5029354259 @default.
- W2010043835 hasAuthorship W2010043835A5042702040 @default.
- W2010043835 hasAuthorship W2010043835A5063329257 @default.
- W2010043835 hasAuthorship W2010043835A5064608982 @default.
- W2010043835 hasAuthorship W2010043835A5066807844 @default.
- W2010043835 hasBestOaLocation W20100438351 @default.
- W2010043835 hasConcept C104317684 @default.
- W2010043835 hasConcept C146587185 @default.
- W2010043835 hasConcept C190283241 @default.
- W2010043835 hasConcept C200784783 @default.
- W2010043835 hasConcept C20251656 @default.
- W2010043835 hasConcept C2779058106 @default.
- W2010043835 hasConcept C2779826832 @default.