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- W2010048343 abstract "Pathological identification of malignant tumour cells in lymphnodes is often difficult although changes may be obvious in the presence of gland-forming metastatic adenocarcinoma or pigmented metastatic malignant melanoma. 1 Weiss LM Chang KL Arber DA Weidner L The difficult diagnosis in surgical pathology. W B Saunders, Philadelphia1996: 805-839 Google Scholar Very few tumour cells or the presence of one or two atypical cells may cause malignant disease to be suspected, but not provide sufficient evidence for correct diagnosis. We report the detection of genetic alterations in morphologically obscure neoplastic cells by single cell genetic analysis with fluorescent in-situ hybridisation (FISH). Molecular staging of cancer: is it time?Occult locoregional spread of cancer is a common cause of local recurrence and an early indicator of subclinical micrometastatic dissemination. Accurate staging of primary tumours is therefore extremely important and may result in either more extensive primary therapy to reduce the risk of local recurrence or systemic adjuvant therapy with the aim of eliminating micrometastasis. Currently staging is histopathological, relies on the identification of malignant cells at surgical margins or in regional lymph nodes, and is often inaccurate. Full-Text PDF" @default.
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- W2010048343 date "1997-07-01" @default.
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- W2010048343 title "Detection of gene deletion in single metastatic tumour cells in lymphnode tissue by fluorescent in-situ hybridisation" @default.
- W2010048343 cites W2010160635 @default.
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- W2010048343 doi "https://doi.org/10.1016/s0140-6736(05)62228-3" @default.
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