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• W2010050730 abstract "Abstract Recent research has suggested that autistic social impairment (ASI) is continuously distributed in nature and that subtle autistic-like social impairments aggregate in the family members of children with pervasive developmental disorders (PDDs). This study examined the longitudinal course of quantitatively characterized ASI in 3- to 18-year-old boys with and without PDD. We obtained assessments of 95 epidemiologically ascertained male–male twin pairs and a clinical sample of 95 affected children using the Social Responsiveness Scale (SRS), at two time points, spaced 1–5 years apart. Longitudinal course was examined as a function of age, familial loading for PDD, and autistic severity at baseline. Interindividual variation in SRS scores was highly preserved over time, with test–retest correlation of 0.90 for the entire sample. SRS scores exhibited modest general improvement over the study period; individual trajectories varied as a function of severity at baseline and were highly familial. Quantitative measurements of ASI reflect heritable traitlike characteristics. Such measurements can serve as reliable indices of phenotypic severity for genetic and neurobiologic studies, and have potential utility for ascertaining incremental response to intervention." @default.
• W2010050730 created "2016-06-24" @default.
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• W2010050730 date "2009-01-01" @default.
• W2010050730 modified "2023-10-16" @default.
• W2010050730 title "Developmental course of autistic social impairment in males" @default.
• W2010050730 cites W1561568624 @default.
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• W2010050730 doi "https://doi.org/10.1017/s095457940900008x" @default.
• W2010050730 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2893041" @default.
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