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• W2010051467 abstract "The bioavailability, duration of action, and efficacy of a crystallized tablet form of theophylline were studied in 16 nonsteroid-dependent asthmatic children. All required bronchodilator drugs daily for control of symptoms. Theophylline 125 mg, ephedrine SO4 30 mg, T+E, or placebo were given in a randomized, double-blind, crossover design on four separate days. Pulmonary function tests (FVC, FEV1, FEF25–75) and serum T levels were determined at 0, 4, 1, 2, 4, and 6 hours on both day one and after day 7 of a every-six-hour drug dosage schedule. Mean maximum T levels were achieved at two hours with a peak mean of 2.94 μg/ml ±0.24 SEM on day one. On day 8, the maximum T levels were higher, with a peak mean at two hours of 4.69 μg/ml ±0.49 SEM. Computer analyses for pharmokinetics are compatible with 100% absorption of this preparation. Pulmonary function tests were significantly improved (FEV1 20% and FEF25–75 15%) at T levels of 2 to 5 μg/ml. Addition of E to the T regimen further improved pulmonary function only on day one and had no effect on the last study day. The bioavailability, duration of action, and efficacy of a crystallized tablet form of theophylline were studied in 16 nonsteroid-dependent asthmatic children. All required bronchodilator drugs daily for control of symptoms. Theophylline 125 mg, ephedrine SO4 30 mg, T+E, or placebo were given in a randomized, double-blind, crossover design on four separate days. Pulmonary function tests (FVC, FEV1, FEF25–75) and serum T levels were determined at 0, 4, 1, 2, 4, and 6 hours on both day one and after day 7 of a every-six-hour drug dosage schedule. Mean maximum T levels were achieved at two hours with a peak mean of 2.94 μg/ml ±0.24 SEM on day one. On day 8, the maximum T levels were higher, with a peak mean at two hours of 4.69 μg/ml ±0.49 SEM. Computer analyses for pharmokinetics are compatible with 100% absorption of this preparation. Pulmonary function tests were significantly improved (FEV1 20% and FEF25–75 15%) at T levels of 2 to 5 μg/ml. Addition of E to the T regimen further improved pulmonary function only on day one and had no effect on the last study day." @default.
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• W2010051467 title "The effectiveness of the short- and long-term use of crystallized theophylline in asthmatic children" @default.
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• W2010051467 doi "https://doi.org/10.1016/s0022-3476(78)80318-7" @default.
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