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- W2010051617 abstract "Three groups of hydrophilic, soluble and biocompatible polymers (poly(hydroxyalkyl acrylates), N-substituted polyacrylamides and polyamides of the polypeptide type) are examined as carriers of various functional groups. Tests showed that polymeric derivatives formed between the original functional groups and pharmacologically active groups possess biological activity. Fluorescent tracers were used to follow the localization of the polymers in the organism at the cell and tissue levels. The results indicates the occurrence of tubular resorption, a process that has not been described previously in pharmakinetics. The reactivity of the functional groups was studied by kinetic methods and by EPR spectroscopy, and it is shown that this depends essentially on the mobility of the side chain joining the reactive group to the main chain, and is determined to a considerable extent also by the nature of the microenvironment, in particular the polarity of the polymeric carrier. In production of polymeric materials for medical purposes it is essential to have complete knowledge of both the effect of the separate factors, and of these factors in combination." @default.
- W2010051617 created "2016-06-24" @default.
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- W2010051617 date "1979-01-01" @default.
- W2010051617 modified "2023-10-16" @default.
- W2010051617 title "Some synthetic polymers with functional groups for biomedical applications" @default.
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- W2010051617 doi "https://doi.org/10.1016/0032-3950(79)90376-9" @default.
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