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• W2010052418 abstract "The goal of this study was to determine the effect of chronic mid-thoracic spinal cord transection on the time course of external urethral sphincter (EUS) and bladder activity associated with micturition events in the rat. Adult female Sprague–Dawley rats, either spinally intact or transected (T9–T10), were anesthetized with urethane and set up for continuous flow urodynamic recording of bladder intravesical pressure (BP) and EUS electromyography (EMG). Spinal transections were performed under isoflurane anesthesia 1–8 weeks prior to the terminal experiment. Four major differences between intact and transected rats were observed: 1) While the frequency of micturition events in the intact rat was dependent upon the rate of bladder filling, the bladder contraction and associated EUS activation in transected rats exhibited an intrinsic rhythm that was independent of the rate of bladder filling and post-transection survival time. 2) EUS activation was augmented at the beginning of active bladder contraction in the transected rat, indicating an amplified guarding reflex. 3) Phasic EUS activity at the peak of bladder contraction (EUS bursting) in the intact rat was markedly reduced or absent in the transected rat. 4) The sustained tonic EUS activity following bladder relaxation in the intact rat was absent in the transected rat. These data are discussed in the context of understanding the pathophysiology of spinal cord injury (SCI) induced destrusor-sphincter dyssynergia (DSD)." @default.
• W2010052418 created "2016-06-24" @default.
• W2010052418 creator A5025491740 @default.
• W2010052418 creator A5053551557 @default.
• W2010052418 creator A5066268678 @default.
• W2010052418 date "2011-03-01" @default.
• W2010052418 modified "2023-10-18" @default.
• W2010052418 title "Quantification of external urethral sphincter and bladder activity during micturition in the intact and spinally transected adult rat" @default.
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• W2010052418 doi "https://doi.org/10.1016/j.expneurol.2010.12.008" @default.
• W2010052418 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21167152" @default.
• W2010052418 hasPublicationYear "2011" @default.
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