FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010053089> ?p ?o ?g. }

• W2010053089 abstract "1. The inhibitory action of caffeine on catecholamine secretion induced by secretagogues was investigated in perfused adrenal glands and dispersed chromaffin cells of the guinea-pig. 2. Caffeine (10 mM) caused a reversible inhibition of catecholamine secretion evoked by acetylcholine (ACh, 50 microM), KCl (56 mM, high K+) and veratridine (100 microM) and that induced by muscarinic receptor activation in the absence of extracellular Ca2+ in perfused adrenal glands. 3. In dispersed chromaffin cells, caffeine caused a dose-dependent inhibition of the secretory responses to 100 microM ACh and veratridine. Forskolin (30 microM), dibutyryl cyclic AMP (1 mM) and 8-bromo cyclic AMP (1 mM) did not mimic the action of caffeine. 4. In the voltage-clamp, whole-cell recording mode (at a holding potential of -60 mV or -70 mV), ACh (100 microM) evoked an inward current, and depolarizing pulses elicited inward Na+, Ca2+ and outward K+ currents. All these responses were partially inhibited by caffeine (20 mM). 5. ACh rapidly increased the intracellular concentration of Ca2+ ([Ca2+]i) in fura-2-loaded cells in either the presence or the absence of external Ca2+, though its magnitude was decreased by about 50% in Ca(2+)-free conditions. Caffeine (20 mM) inhibited these ACh-induced increases in [Ca2+]i. 6. In permeabilized chromaffin cells, caffeine (20 mM) caused an inhibition of catecholamine secretion evoked by Ca2+ (10 microM). 7. These results suggest that caffeine inhibits evoked catecholamine secretion through mechanisms such as the blockade of voltage-dependent Na+ and Ca2+ currents and ACh receptor current, and reduction of the release of intracellularly stored Ca2+ and/or Ca(2+)-sensitivity of the secretory apparatus." @default.
• W2010053089 created "2016-06-24" @default.
• W2010053089 creator A5016430909 @default.
• W2010053089 creator A5018876820 @default.
• W2010053089 creator A5035670774 @default.
• W2010053089 creator A5048502355 @default.
• W2010053089 creator A5051205126 @default.
• W2010053089 creator A5064125582 @default.
• W2010053089 creator A5086059561 @default.
• W2010053089 date "1994-03-01" @default.
• W2010053089 modified "2023-10-12" @default.
• W2010053089 title "Inhibitory effects of caffeine on secretagogue-induced catecholamine secretion from adrenal chromaffin cells of the guinea-pig" @default.
• W2010053089 cites W1507967068 @default.
• W2010053089 cites W1602784471 @default.
• W2010053089 cites W1842519451 @default.
• W2010053089 cites W1956859188 @default.
• W2010053089 cites W1966886300 @default.
• W2010053089 cites W1967166654 @default.
• W2010053089 cites W1986587786 @default.
• W2010053089 cites W1996024251 @default.
• W2010053089 cites W1997511216 @default.
• W2010053089 cites W2006439164 @default.
• W2010053089 cites W2006926451 @default.
• W2010053089 cites W2009667219 @default.
• W2010053089 cites W2011390733 @default.
• W2010053089 cites W2015426350 @default.
• W2010053089 cites W2019325958 @default.
• W2010053089 cites W2024988208 @default.
• W2010053089 cites W2026202296 @default.
• W2010053089 cites W2029418421 @default.
• W2010053089 cites W2033773107 @default.
• W2010053089 cites W2036877865 @default.
• W2010053089 cites W2037935249 @default.
• W2010053089 cites W2038389631 @default.
• W2010053089 cites W2040980719 @default.
• W2010053089 cites W2050389355 @default.
• W2010053089 cites W2055305077 @default.
• W2010053089 cites W2061523074 @default.
• W2010053089 cites W2068228019 @default.
• W2010053089 cites W2092091509 @default.
• W2010053089 cites W2141260882 @default.
• W2010053089 cites W2153275719 @default.
• W2010053089 cites W2267440579 @default.
• W2010053089 cites W4242856654 @default.
• W2010053089 cites W1971237088 @default.
• W2010053089 doi "https://doi.org/10.1111/j.1476-5381.1994.tb14829.x" @default.
• W2010053089 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1910062" @default.
• W2010053089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8019771" @default.
• W2010053089 hasPublicationYear "1994" @default.
• W2010053089 type Work @default.
• W2010053089 sameAs 2010053089 @default.
• W2010053089 citedByCount "8" @default.
• W2010053089 crossrefType "journal-article" @default.
• W2010053089 hasAuthorship W2010053089A5016430909 @default.
• W2010053089 hasAuthorship W2010053089A5018876820 @default.
• W2010053089 hasAuthorship W2010053089A5035670774 @default.
• W2010053089 hasAuthorship W2010053089A5048502355 @default.
• W2010053089 hasAuthorship W2010053089A5051205126 @default.
• W2010053089 hasAuthorship W2010053089A5064125582 @default.
• W2010053089 hasAuthorship W2010053089A5086059561 @default.
• W2010053089 hasBestOaLocation W20100530892 @default.
• W2010053089 hasConcept C126322002 @default.
• W2010053089 hasConcept C134018914 @default.
• W2010053089 hasConcept C178790620 @default.
• W2010053089 hasConcept C185592680 @default.
• W2010053089 hasConcept C24998067 @default.
• W2010053089 hasConcept C2775894120 @default.
• W2010053089 hasConcept C2775910092 @default.
• W2010053089 hasConcept C2776986425 @default.
• W2010053089 hasConcept C2777597313 @default.
• W2010053089 hasConcept C2778500429 @default.
• W2010053089 hasConcept C2779276759 @default.
• W2010053089 hasConcept C2780161494 @default.
• W2010053089 hasConcept C2780910648 @default.
• W2010053089 hasConcept C4141045 @default.
• W2010053089 hasConcept C49039625 @default.
• W2010053089 hasConcept C50952357 @default.
• W2010053089 hasConcept C537181965 @default.
• W2010053089 hasConcept C71924100 @default.
• W2010053089 hasConcept C86803240 @default.
• W2010053089 hasConceptScore W2010053089C126322002 @default.
• W2010053089 hasConceptScore W2010053089C134018914 @default.
• W2010053089 hasConceptScore W2010053089C178790620 @default.
• W2010053089 hasConceptScore W2010053089C185592680 @default.
• W2010053089 hasConceptScore W2010053089C24998067 @default.
• W2010053089 hasConceptScore W2010053089C2775894120 @default.
• W2010053089 hasConceptScore W2010053089C2775910092 @default.
• W2010053089 hasConceptScore W2010053089C2776986425 @default.
• W2010053089 hasConceptScore W2010053089C2777597313 @default.
• W2010053089 hasConceptScore W2010053089C2778500429 @default.
• W2010053089 hasConceptScore W2010053089C2779276759 @default.
• W2010053089 hasConceptScore W2010053089C2780161494 @default.
• W2010053089 hasConceptScore W2010053089C2780910648 @default.
• W2010053089 hasConceptScore W2010053089C4141045 @default.
• W2010053089 hasConceptScore W2010053089C49039625 @default.
• W2010053089 hasConceptScore W2010053089C50952357 @default.
• W2010053089 hasConceptScore W2010053089C537181965 @default.
• W2010053089 hasConceptScore W2010053089C71924100 @default.
• W2010053089 hasConceptScore W2010053089C86803240 @default.
• W2010053089 hasLocation W20100530891 @default.

• next