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• W2010053536 abstract "The ubiquitous feline intraerythrocytic pathogen Bartonella henselae causes a range of important human infections, and seroprevalence in blood donors in Australia is around 5% (6). Two antigenically distinct subtypes have been described, named for the type strain (Houston-1) and the more recently recognized Marseille strain (5), which have characteristic DNA sequences in the 16S rRNA gene (rDNA) and the gltA (citrate synthase) gene (2, 3, 5). Culture of this fastidious, gram-negative bacterium is difficult, and serology is a primary diagnostic approach. A recent report that Houston-like strains (including Houston-1, 90-615, and SA-2) may be distinguished from serologically distinct Marseille-like strains (including URBHLLY-8, URBHLIE-9, Fizz, and CAL-1) by the faster migration of a characteristic band (ca. 29 kDa) on sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) analysis and immunoblotting of whole-cell lysates is therefore particularly noteworthy (7).However, the SDS-PAGE data appear to contrast with previous publications from the same laboratory (8, 9) and others (11). We therefore compared local human isolates with the Houston-1 and Marseille strains and also found two closely related genotypes with corresponding patterns on SDS-PAGE of whole-cell lysates (Fig. ​(Fig.1).1). All human strains appear to have either the 30-kDa band (Houston) or the 29-kDa band (Marseille), in agreement with earlier studies (10, 11). The agar-pitting colony phenotype and number of in vitro passages have no apparent influence (Fig. ​(Fig.11 and Table ​Table1).1). However, a local feline strain of the type II (Marseille-like) 16S rDNA genotype has the faster-migrating (29-kDa) band and a gltA gene sequence typical of Houston strains, consistent with the considerable diversity known to exist in feline strains (1, 10) and illustrating a dissociation of the accepted genotype-phenotype relationships. The strains in the recent study (7) were all human isolates and were assigned to genotypes by individual sequencing of several genes, including groEL (12) and the 16S rDNA (3). While the 29- to 30-kDa antigen(s) may yet prove useful for serotyping of human isolates, it thus seems unlikely that reported inconsistencies in the data can be easily explained by phase variation or genotype. In addition, we have no reason to assume that the more diverse feline strains are all nonpathogenic in humans. For both of thesereasons, we therefore urge caution in adopting this promising target as a basis for serotype distinction until the picture is clearer.FIG. 1.Marseille and Houston types. Coomassie-stained SDS-PAGE of whole-cell lysates harvested from chocolate agar plates (grown at 35°C in 5% CO2). High-molecular-weight (lane 1 and left border) and low-molecular-weight (right border) markers are shown, ...TABLE 1.B. henselae isolates used in this study" @default.
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• W2010053536 date "2002-11-01" @default.
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• W2010053536 title "Antigenic and Genotypic Relationships between Bartonella henselae Strains" @default.
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• W2010053536 doi "https://doi.org/10.1128/jcm.40.11.4397-4398.2002" @default.
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