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• W2010055022 abstract "A very large oxidative damage rate to DNA occurs as part of normal metabolism. In each rat cell the steady-state level is estimated to be about 106 oxidative adducts and about 105 new adducts are formed daily. It is argued that this endogenous DNA damage is a major contributor to aging and the degenerative diseases of aging, such as cancer. The oxidative damage rate in mammalian species with a high metabolic rate, short life span, and high age-specific cancer rate is much higher than the rate in humans, a long-lived creature with a lower metabolic rate and a lower age-specific cancer rate. It is argured that deficiency of micronutrients, such as dietary antioxidants or folate, is a major contributor to human cancer and degenerative diseases. Understanding the role of mitogenesis in mutagenesis is critical for clarifying the mechanisms of carcinogenesis and interpreting high-dose animal cancer tests. High-dose animal cancer tests have been done mainly on synthetic industrial chemicals, yet almost all of the chemicals humans are exposed to are natural. About half of natural chemicals tested in high-dose animal cancer tests are rodent carcinogens, a finding that is consistent with the view that high-dose tests frequently increase mitogenesis rates. Animals have numerous defenses against toxins that make them very well buffered against low doses of almost all toxins, whether synthetic or natural." @default.
• W2010055022 created "2016-06-24" @default.
• W2010055022 creator A5047067531 @default.
• W2010055022 creator A5047956908 @default.
• W2010055022 date "1991-09-01" @default.
• W2010055022 modified "2023-10-13" @default.
• W2010055022 title "Endogenous mutagens and the causes of aging and cancer" @default.
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• W2010055022 doi "https://doi.org/10.1016/0027-5107(91)90157-j" @default.
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