FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010055392> ?p ?o ?g. }

• W2010055392 endingPage "348.e1" @default.
• W2010055392 startingPage "341" @default.
• W2010055392 abstract "To investigate if plasma DNA is elevated in patients with deep vein thrombosis (DVT) and to determine whether there is a correlation with other biomarkers of DVT.Leukocytes release DNA to form extracellular traps (ETs), which have recently been linked to experimental DVT. In baboons and mice, extracellular DNA co-localized with von Willebrand factor (VWF) in the thrombus and DNA appeared in circulation at the time of thrombus formation. ETs have not been associated with clinical DVT.From December 2008 to August 2010, patients were screened through the University of Michigan Diagnostic Vascular Unit and were divided into three distinct groups: 1) the DVT positive group, consisting of patients who were symptomatic for DVT, which was confirmed by compression duplex ultrasound (n=47); 2) the DVT negative group, consisting of patients that present with swelling and leg pain but had a negative compression duplex ultrasound, (n=28); and 3) a control group of healthy non-pregnant volunteers without signs or symptoms of active or previous DVT (n=19). Patients were excluded if they were less than 18 years of age, unwillingness to consent, pregnant, on an anticoagulant therapy, or diagnosed with isolated calf vein thrombosis.Blood was collected for circulating DNA, CRP, D-dimer, VWF activity, myeloperoxidase (MPO), ADAMTS13 and VWF. The Wells score for a patient's risk of DVT was assessed. The Receiver Operating Characteristic (ROC) curve was generated to determine the strength of the relationship between circulating DNA levels and the presence of DVT. A Spearman correlation was performed to determine the relationship between the DNA levels and the biomarkers and the Wells score. Additionally the ratio of ADAMTS13/VWF was assessed.Our results showed that circulating DNA (a surrogate marker for NETs) was significantly elevated in DVT patients, compared to both DVT negative patients (57.7±6.3 vs. 17.9±3.5ng/mL, P<.01) and controls (57.7±6.3 vs. 23.9±2.1ng/mL, P<.01). There was a strong positive correlation with CRP (P<.01), D-dimer (P<.01), VWF (P<.01), Wells score (P<.01) and myeloperoxidase (MPO) (P<.01), along with a strong negative correlation with ADAMTS13 (P<.01) and the ADAMTS13/VWF ratio. The logistic regression model showed a strong association between plasma DNA and the presence of DVT (ROC curve was determined to be 0.814).Plasma DNA is elevated in patients with deep vein thrombosis and correlates with biomarkers of DVT. A strong correlation between circulating DNA and MPO suggests that neutrophils may be a source of plasma DNA in patients with DVT." @default.
• W2010055392 created "2016-06-24" @default.
• W2010055392 creator A5013911322 @default.
• W2010055392 creator A5032584210 @default.
• W2010055392 creator A5035826935 @default.
• W2010055392 creator A5038668996 @default.
• W2010055392 creator A5054173938 @default.
• W2010055392 creator A5054711465 @default.
• W2010055392 creator A5058935102 @default.
• W2010055392 creator A5075997575 @default.
• W2010055392 creator A5088390269 @default.
• W2010055392 date "2013-10-01" @default.
• W2010055392 modified "2023-10-06" @default.
• W2010055392 title "Plasma DNA is elevated in patients with deep vein thrombosis" @default.
• W2010055392 cites W1967765437 @default.
• W2010055392 cites W1969463403 @default.
• W2010055392 cites W1970055715 @default.
• W2010055392 cites W1970156474 @default.
• W2010055392 cites W1979952618 @default.
• W2010055392 cites W1994749414 @default.
• W2010055392 cites W2006679777 @default.
• W2010055392 cites W2025102161 @default.
• W2010055392 cites W2030337128 @default.
• W2010055392 cites W2033536448 @default.
• W2010055392 cites W2042544679 @default.
• W2010055392 cites W2045819100 @default.
• W2010055392 cites W2064693934 @default.
• W2010055392 cites W2067022007 @default.
• W2010055392 cites W2067716683 @default.
• W2010055392 cites W2073707438 @default.
• W2010055392 cites W2079743824 @default.
• W2010055392 cites W2101675655 @default.
• W2010055392 cites W2104934425 @default.
• W2010055392 cites W2112543741 @default.
• W2010055392 cites W2118217258 @default.
• W2010055392 cites W2134923719 @default.
• W2010055392 cites W2139719760 @default.
• W2010055392 cites W2150121055 @default.
• W2010055392 cites W2152502508 @default.
• W2010055392 cites W2154414111 @default.
• W2010055392 cites W2170663692 @default.
• W2010055392 cites W2172191543 @default.
• W2010055392 doi "https://doi.org/10.1016/j.jvsv.2012.12.002" @default.
• W2010055392 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3810974" @default.
• W2010055392 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24187669" @default.
• W2010055392 hasPublicationYear "2013" @default.
• W2010055392 type Work @default.
• W2010055392 sameAs 2010055392 @default.
• W2010055392 citedByCount "94" @default.
• W2010055392 countsByYear W20100553922014 @default.
• W2010055392 countsByYear W20100553922015 @default.
• W2010055392 countsByYear W20100553922016 @default.
• W2010055392 countsByYear W20100553922017 @default.
• W2010055392 countsByYear W20100553922018 @default.
• W2010055392 countsByYear W20100553922019 @default.
• W2010055392 countsByYear W20100553922020 @default.
• W2010055392 countsByYear W20100553922021 @default.
• W2010055392 countsByYear W20100553922022 @default.
• W2010055392 countsByYear W20100553922023 @default.
• W2010055392 crossrefType "journal-article" @default.
• W2010055392 hasAuthorship W2010055392A5013911322 @default.
• W2010055392 hasAuthorship W2010055392A5032584210 @default.
• W2010055392 hasAuthorship W2010055392A5035826935 @default.
• W2010055392 hasAuthorship W2010055392A5038668996 @default.
• W2010055392 hasAuthorship W2010055392A5054173938 @default.
• W2010055392 hasAuthorship W2010055392A5054711465 @default.
• W2010055392 hasAuthorship W2010055392A5058935102 @default.
• W2010055392 hasAuthorship W2010055392A5075997575 @default.
• W2010055392 hasAuthorship W2010055392A5088390269 @default.
• W2010055392 hasBestOaLocation W20100553922 @default.
• W2010055392 hasConcept C126322002 @default.
• W2010055392 hasConcept C134897094 @default.
• W2010055392 hasConcept C141071460 @default.
• W2010055392 hasConcept C164705383 @default.
• W2010055392 hasConcept C2776265017 @default.
• W2010055392 hasConcept C2776914184 @default.
• W2010055392 hasConcept C2778959117 @default.
• W2010055392 hasConcept C2779394231 @default.
• W2010055392 hasConcept C2780868729 @default.
• W2010055392 hasConcept C2780921031 @default.
• W2010055392 hasConcept C2781362458 @default.
• W2010055392 hasConcept C58471807 @default.
• W2010055392 hasConcept C71924100 @default.
• W2010055392 hasConcept C89560881 @default.
• W2010055392 hasConcept C90924648 @default.
• W2010055392 hasConceptScore W2010055392C126322002 @default.
• W2010055392 hasConceptScore W2010055392C134897094 @default.
• W2010055392 hasConceptScore W2010055392C141071460 @default.
• W2010055392 hasConceptScore W2010055392C164705383 @default.
• W2010055392 hasConceptScore W2010055392C2776265017 @default.
• W2010055392 hasConceptScore W2010055392C2776914184 @default.
• W2010055392 hasConceptScore W2010055392C2778959117 @default.
• W2010055392 hasConceptScore W2010055392C2779394231 @default.
• W2010055392 hasConceptScore W2010055392C2780868729 @default.
• W2010055392 hasConceptScore W2010055392C2780921031 @default.
• W2010055392 hasConceptScore W2010055392C2781362458 @default.
• W2010055392 hasConceptScore W2010055392C58471807 @default.
• W2010055392 hasConceptScore W2010055392C71924100 @default.

• next