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• W2010055461 abstract "Objectives Bacillus Calmette-Guérin (BCG) and interferon alpha-2b (IFNα2b) have been used individually for the treatment of bladder cancer. We used a low dose of BCG combined with IFNα2b to determine the safety and to assess the efficacy of this combination therapy. Methods A study of 12 patients with superficial bladder cancer evaluated the safety and efficacy of a combination of low-dose BCG and IFNα2b, given weekly for 6 weeks. Three patients were assigned to each of four groups in which 60 mg of BCG was combined with 10, 30, 60, or 100 × 106 ILJ of IFNα2b. Results The combination BCG/IFNα2b therapy was well tolerated, with adverse effects being mild to moderate and resolved at the end of treatment. At 12 months post-treatment there has been no tumor progression. Two patients with previous multifocal transitional cell carcinoma have had solitary recurrences. One patient has had recurrent carcinoma in situ. Conclusions This preliminary study found combination BCG/IFNα2b induction therapy to be safe and well tolerated. These early results show a high response rate, but efficacy can only be determined with Phase II and III studies." @default.
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• W2010055461 date "1996-12-01" @default.
• W2010055461 modified "2023-10-14" @default.
• W2010055461 title "Bacillus calmette-Guérin plus intravesical interferon alpha-2b in patients with superficial bladder cancer" @default.
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• W2010055461 doi "https://doi.org/10.1016/s0090-4295(96)00375-5" @default.
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