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- W2010055562 abstract "Certain flavonoids having a C-2,3-double bond were reported to show an inhibitory activity against T-lymphocyte proliferation, but not against B-lymphocyte proliferation in vitro. In the course of these studies, vitexicarpin (3′,5-dihydroxy-3,4′,6,7-tetramethoxyflavone) isolated from the fruits of Vitex rotundifolia was found to show potent inhibition against lymphocyte proliferation. Vitexicarpin inhibited T-lymphocyte proliferation as well as B-lymphocyte proliferation at > 0.1 µM. IC50's were approximately 0.7 µM both for T- and B-cell proliferation. The inhibitory activity of vitexicarpin was reversible. Vitexicarpin also inhibited the growth of certain cancer cell lines, EL-4 and P815.9 (IC50 = 0.25-0.3 µM). These results suggest that vitexicarpin may be a potential therapeutic agent involved in inflammatory/immunoregulatory disorders such as rheumatoid arthritis and lymphomas." @default.
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- W2010055562 title "Vitexicarpin, a Flavonoid from the Fruits of<i>Vitex rotundifolia</i>, Inhibits Mouse Lymphocyte Proliferation and Growth of Cell Lines<i>in Vitro</i>" @default.
- W2010055562 doi "https://doi.org/10.1055/s-2006-957511" @default.
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