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• W2010056740 abstract "Hyperpolarization-activated inward current ( I h ) has been shown to be involved in production of bursting during various forms of rhythmic activity. However, details of I h in spinal interneurons related to locomotion remain unknown. Using Cfos-EGFP transgenic mice (P6–P12) we are able to target the spinal interneurons activated by locomotion. Following a locomotor task, whole cell patch-clamp recordings were obtained from ventral EGFP+ neurons in spinal cord slices (T 13 –L 4 , 200–250 μm). I h was found in 51% of EGFP+ neurons ( n = 149) with almost even distribution in lamina VII (51%), VIII (47%), and X (55%). I h could be blocked by ZD7288 (10–20 μM) or cesium (1–1.5 mM) but was insensitive to barium (2–2.5 mM). I h activated at −80.1 ± 9.2 mV with half-maximal activation −95.5 ± 13.3 mV, activation rate 10.0 ± 3.2 mV, time constant 745 ± 501 ms, maximal conductance 1.0 ± 0.7 nS, and reversal potential −34.3 ± 3.6 mV. 5-HT (15–20 μM) and ACh (20–30 μM) produced variable effects on I h . 5-HT increased I h in 43% of EGFP+ neurons ( n = 37), decreased I h in 24%, and had no effect on I h in 33% of the neurons. ACh decreased I h in 67% of EGFP+ neurons ( n = 18) with unchanged I h in 33% of the neurons. This study characterizes the I h in locomotor-related interneurons and is the first to demonstrate the variable effects of 5-HT and ACh on I h in rodent spinal interneurons. The finding of 5-HT and ACh-induced reduction of I h in EGFP+ neurons suggests a novel mechanism that the motor system could use to limit the participation of certain neurons in locomotion." @default.
• W2010056740 created "2016-06-24" @default.
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• W2010056740 date "2010-07-01" @default.
• W2010056740 modified "2023-10-06" @default.
• W2010056740 title "Multiple Effects of Serotonin and Acetylcholine on Hyperpolarization-Activated Inward Current in Locomotor Activity-Related Neurons in Cfos-EGFP Mice" @default.
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• W2010056740 doi "https://doi.org/10.1152/jn.01110.2009" @default.
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