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- W2010059934 abstract "The current recombinant hepatitis B vaccines are safe and effective. However, the occurrence of non-responders and difficulties in immunizing immunodeficient persons suggest the need for further improvements. Recent data suggest that the pre-S2 and pre-S1 domains of hepatitis B virus induced protective antibodies. The good T-helper response against pre-S1 epitopes would also improve the antibody response against the small surface antigen protein. An even better T-cell priming could be achieved by including hepatitis B core (HBc) proteins or peptides. An optimal immunogen would contain all three proteins comprising hepatitis B surface antigen in their natural conformation and glycosylation as well as the major T-cell epitopes of HBc." @default.
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- W2010059934 date "1990-03-01" @default.
- W2010059934 modified "2023-09-23" @default.
- W2010059934 title "Protective potential of hepatitis B virus antigens other than the S gene protein" @default.
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- W2010059934 doi "https://doi.org/10.1016/0264-410x(90)90220-g" @default.
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