FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010060980> ?p ?o ?g. }

• W2010060980 endingPage "142" @default.
• W2010060980 startingPage "134" @default.
• W2010060980 abstract "ATP and its metabolite adenosine activate membrane receptors, termed P2 and P1, respectively. In the present study, the modulation of the mesolimbic neuronal circuit by ATPergic and adenosinergic mechanisms was investigated by microdialysis in the nucleus accumbens (NAc) and by telemetrically recorded EEG from both the NAc and the ventral tegmental area (VTA) of freely moving rats. The basal extracellular dopamine concentration was enhanced after accumbal perfusion with the ATP analog 2-methylthio ATP (2-MeSATP; 100 microM); by contrast, adenosine (100 microM) caused a reduction of extracellular dopamine. When given alone, the P2 receptor antagonist pyridoxalphosphate-6-azophenyl-2',4'-disulphonic acid (PPADS; 20 microM) decreased the concentration of dopamine, whereas the P1 receptor antagonist 8-(p-sulfophenyl)theophylline (8-SPT; 100 microM) increased it. In the same animals, P2 receptor stimulation by 2-MeSATP caused neuronal activation, indicated by an elevation of the absolute power in the EEG of the NAc mainly by enhancement of the relative power in the alpha band (8-13 Hz) of the EEG spectrum. By contrast, adenosine led to a depression of the absolute power in the VTA accompanied by an elevation of the delta-band power (0.4-6 Hz) in the NAc corresponding to a slowing of neuronal activity. When given alone, PPADS reduced the absolute EEG power in the NAc accompanied by a decrease in the high-frequency power, but had no effects on the VTA. 8-SPT on its own enhanced the total power in both the NAc and the VTA, reflected by an enhancement in the slow and the high-frequency bands. Whereas the 8-SPT-evoked changes of EEG pattern as well as of dopamine concentration in the NAc were abolished by the co-application of PPADS, the 8-SPT-induced EEG changes in the VTA persisted under these conditions. In conclusion, the accumbal neuronal output, reflected by both dopamine release and neuronal electrical activity, is modulated in a functionally antagonistic manner by P2 and P1 receptor stimulation. It is suggested that an inhibitory GABAergic feedback projection to the VTA is stimulated by adenosine, either directly or indirectly via glutamate release." @default.
• W2010060980 created "2016-06-24" @default.
• W2010060980 creator A5016125373 @default.
• W2010060980 creator A5028318519 @default.
• W2010060980 creator A5079719834 @default.
• W2010060980 creator A5081745338 @default.
• W2010060980 date "2002-11-26" @default.
• W2010060980 modified "2023-10-15" @default.
• W2010060980 title "Purinergic modulation of neuronal activity in the mesolimbic dopaminergic system in vivo" @default.
• W2010060980 cites W1502439265 @default.
• W2010060980 cites W1551550807 @default.
• W2010060980 cites W1608256683 @default.
• W2010060980 cites W1860258914 @default.
• W2010060980 cites W1964805227 @default.
• W2010060980 cites W1966237163 @default.
• W2010060980 cites W1970602039 @default.
• W2010060980 cites W1971035825 @default.
• W2010060980 cites W1972040137 @default.
• W2010060980 cites W1977592396 @default.
• W2010060980 cites W1980746508 @default.
• W2010060980 cites W1985060592 @default.
• W2010060980 cites W1999435825 @default.
• W2010060980 cites W2000703659 @default.
• W2010060980 cites W2005786584 @default.
• W2010060980 cites W2011649118 @default.
• W2010060980 cites W2012167462 @default.
• W2010060980 cites W2023328664 @default.
• W2010060980 cites W2023505630 @default.
• W2010060980 cites W2023563819 @default.
• W2010060980 cites W2026079005 @default.
• W2010060980 cites W2027247042 @default.
• W2010060980 cites W2033777548 @default.
• W2010060980 cites W2038093755 @default.
• W2010060980 cites W2038433623 @default.
• W2010060980 cites W2045349348 @default.
• W2010060980 cites W2045743982 @default.
• W2010060980 cites W2051509267 @default.
• W2010060980 cites W2053269045 @default.
• W2010060980 cites W2055771038 @default.
• W2010060980 cites W2060183829 @default.
• W2010060980 cites W2060332215 @default.
• W2010060980 cites W2066093807 @default.
• W2010060980 cites W2071489012 @default.
• W2010060980 cites W2083868750 @default.
• W2010060980 cites W2091199294 @default.
• W2010060980 cites W2091858384 @default.
• W2010060980 cites W2092407378 @default.
• W2010060980 cites W2102386138 @default.
• W2010060980 cites W2105574305 @default.
• W2010060980 cites W2117520655 @default.
• W2010060980 cites W2119327355 @default.
• W2010060980 cites W2122592499 @default.
• W2010060980 cites W2136306454 @default.
• W2010060980 cites W2138599948 @default.
• W2010060980 cites W2160262187 @default.
• W2010060980 cites W2199584277 @default.
• W2010060980 doi "https://doi.org/10.1002/syn.10162" @default.
• W2010060980 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12454951" @default.
• W2010060980 hasPublicationYear "2002" @default.
• W2010060980 type Work @default.
• W2010060980 sameAs 2010060980 @default.
• W2010060980 citedByCount "64" @default.
• W2010060980 countsByYear W20100609802012 @default.
• W2010060980 countsByYear W20100609802013 @default.
• W2010060980 countsByYear W20100609802014 @default.
• W2010060980 countsByYear W20100609802015 @default.
• W2010060980 countsByYear W20100609802016 @default.
• W2010060980 countsByYear W20100609802017 @default.
• W2010060980 countsByYear W20100609802018 @default.
• W2010060980 countsByYear W20100609802019 @default.
• W2010060980 countsByYear W20100609802020 @default.
• W2010060980 countsByYear W20100609802021 @default.
• W2010060980 countsByYear W20100609802023 @default.
• W2010060980 crossrefType "journal-article" @default.
• W2010060980 hasAuthorship W2010060980A5016125373 @default.
• W2010060980 hasAuthorship W2010060980A5028318519 @default.
• W2010060980 hasAuthorship W2010060980A5079719834 @default.
• W2010060980 hasAuthorship W2010060980A5081745338 @default.
• W2010060980 hasConcept C126322002 @default.
• W2010060980 hasConcept C134018914 @default.
• W2010060980 hasConcept C137183658 @default.
• W2010060980 hasConcept C169760540 @default.
• W2010060980 hasConcept C170493617 @default.
• W2010060980 hasConcept C185592680 @default.
• W2010060980 hasConcept C2776552330 @default.
• W2010060980 hasConcept C2776991684 @default.
• W2010060980 hasConcept C2776992512 @default.
• W2010060980 hasConcept C2778938600 @default.
• W2010060980 hasConcept C2780019924 @default.
• W2010060980 hasConcept C2780410667 @default.
• W2010060980 hasConcept C2780634109 @default.
• W2010060980 hasConcept C2780948874 @default.
• W2010060980 hasConcept C50156730 @default.
• W2010060980 hasConcept C513476851 @default.
• W2010060980 hasConcept C55493867 @default.
• W2010060980 hasConcept C57306754 @default.
• W2010060980 hasConcept C67907053 @default.
• W2010060980 hasConcept C71924100 @default.

• next