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• W2010061474 abstract "In the absence of the telomerase, telomeres undergo progressive shortening and are ultimately recruited into end-to-end chromosome fusions via the non-homologous end joining (NHEJ) double-strand break repair pathway. Previously, we showed that fusion of critically shortened telomeres in Arabidopsis proceeds with approximately the same efficiency in the presence or absence of KU70, a key component of NHEJ. Here we report that DNA ligase IV (LIG4) is also not essential for telomere joining. We observed only a modest decrease (3-fold) in the frequency of chromosome fusions in triple tert ku70 lig4 mutants versus tert ku70 or tert . Sequence analysis revealed that, relative to tert ku70 , chromosome fusion junctions in tert ku70 lig4 mutants contained less microhomology and less telomeric DNA. These findings argue that the KU-LIG4 independent end-joining pathway is less efficient and mechanistically distinct from KU-independent NHEJ. Strikingly, in all the genetic backgrounds we tested, chromosome fusions are initiated when the shortest telomere in the population reaches ∼ 1 kb, implying that this size represents a critical threshold that heralds a detrimental structural transition. These data reveal the transitory nature of telomere stability, and the robust and flexible nature of DNA repair mechanisms elicited by telomere dysfunction." @default.
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• W2010061474 date "2007-10-16" @default.
• W2010061474 modified "2023-10-15" @default.
• W2010061474 title "Telomere dynamics and fusion of critically shortened telomeres in plants lacking DNA ligase IV" @default.
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• W2010061474 doi "https://doi.org/10.1093/nar/gkm472" @default.
• W2010061474 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2095805" @default.
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