FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010063556> ?p ?o ?g. }

• W2010063556 endingPage "466" @default.
• W2010063556 startingPage "457" @default.
• W2010063556 abstract "Radioimmunotherapy is limited by the absorbed dose to radiosensitive organs. Removal of circulating radiolabeled MAbs after tumor tissue has been optimally targeted and should permit the administration of higher radioactivity to patients, resulting in a higher absorbed tumor dose. A novel extracorporeal affinity adsorption treatment (ECAT) device (MitraDep®) was tested, with which biotinylated and radiolabeled MAbs can be removed from the circulation by passing whole blood over a filter coated with avidin. The antibodies were simultaneously radiolabeled and biotinylated using a trifunctional moiety comprising DOTA and biotin. Eight patients—all but 1 of whom with aggressive or mantle cell B-cell lymphoma— who had failed to respond to standard therapies received infusions of 250 mg/m2 cold rituximab and 150 MBq 111In-rituximab-biotin for immunoscintigraphy. A week later, the patients were treated with another 250 mg/m2 rituximab followed by 111In/-90Y-rituximab-biotin (11 or 15 90Y MBq/kg). ECAT was performed 48 hours later. All 8 patients receiving 111In-rituximab-biotin showed tumor uptake. Seven patients received radioimmunotherapy and subsequent ECAT. The mean depletion of 90Y-rituximab-biotin in whole blood after ECAT was 96%, in the whole body 49%, in the lungs 62%, and in the liver and kidneys 40%. No effects on patients' vital signs and no adverse effects on hematological or coagulation parameters was observed during the ECAT procedure. A dose-escalation study is initiated." @default.
• W2010063556 created "2016-06-24" @default.
• W2010063556 creator A5000143923 @default.
• W2010063556 creator A5005310278 @default.
• W2010063556 creator A5009201915 @default.
• W2010063556 creator A5012218042 @default.
• W2010063556 creator A5033422633 @default.
• W2010063556 creator A5034366800 @default.
• W2010063556 creator A5050258103 @default.
• W2010063556 creator A5051011281 @default.
• W2010063556 creator A5076381883 @default.
• W2010063556 creator A5086372495 @default.
• W2010063556 date "2005-08-01" @default.
• W2010063556 modified "2023-10-02" @default.
• W2010063556 title "A Novel Platform for Radioimmunotherapy: Extracorporeal Depletion of Biotinylated and ⁹⁰Y-Labeled Rituximab in Patients with Refractory B-Cell Lymphoma" @default.
• W2010063556 cites W1892026381 @default.
• W2010063556 cites W1915689252 @default.
• W2010063556 cites W1966519301 @default.
• W2010063556 cites W2026305248 @default.
• W2010063556 cites W2039698972 @default.
• W2010063556 cites W2052000503 @default.
• W2010063556 cites W2062239082 @default.
• W2010063556 cites W2063708816 @default.
• W2010063556 cites W2077147663 @default.
• W2010063556 cites W2080824264 @default.
• W2010063556 cites W2110422885 @default.
• W2010063556 cites W2135157531 @default.
• W2010063556 cites W2164006259 @default.
• W2010063556 cites W2256690185 @default.
• W2010063556 cites W2267583049 @default.
• W2010063556 cites W4231724325 @default.
• W2010063556 doi "https://doi.org/10.1089/cbr.2005.20.457" @default.
• W2010063556 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16114994" @default.
• W2010063556 hasPublicationYear "2005" @default.
• W2010063556 type Work @default.
• W2010063556 sameAs 2010063556 @default.
• W2010063556 citedByCount "32" @default.
• W2010063556 countsByYear W20100635562012 @default.
• W2010063556 countsByYear W20100635562013 @default.
• W2010063556 countsByYear W20100635562015 @default.
• W2010063556 countsByYear W20100635562016 @default.
• W2010063556 countsByYear W20100635562019 @default.
• W2010063556 crossrefType "journal-article" @default.
• W2010063556 hasAuthorship W2010063556A5000143923 @default.
• W2010063556 hasAuthorship W2010063556A5005310278 @default.
• W2010063556 hasAuthorship W2010063556A5009201915 @default.
• W2010063556 hasAuthorship W2010063556A5012218042 @default.
• W2010063556 hasAuthorship W2010063556A5033422633 @default.
• W2010063556 hasAuthorship W2010063556A5034366800 @default.
• W2010063556 hasAuthorship W2010063556A5050258103 @default.
• W2010063556 hasAuthorship W2010063556A5051011281 @default.
• W2010063556 hasAuthorship W2010063556A5076381883 @default.
• W2010063556 hasAuthorship W2010063556A5086372495 @default.
• W2010063556 hasConcept C126322002 @default.
• W2010063556 hasConcept C159654299 @default.
• W2010063556 hasConcept C185592680 @default.
• W2010063556 hasConcept C203014093 @default.
• W2010063556 hasConcept C2776146153 @default.
• W2010063556 hasConcept C2777064799 @default.
• W2010063556 hasConcept C2777836882 @default.
• W2010063556 hasConcept C2778204606 @default.
• W2010063556 hasConcept C2779338263 @default.
• W2010063556 hasConcept C2780653079 @default.
• W2010063556 hasConcept C542903549 @default.
• W2010063556 hasConcept C55493867 @default.
• W2010063556 hasConcept C71924100 @default.
• W2010063556 hasConcept C90924648 @default.
• W2010063556 hasConcept C98274493 @default.
• W2010063556 hasConceptScore W2010063556C126322002 @default.
• W2010063556 hasConceptScore W2010063556C159654299 @default.
• W2010063556 hasConceptScore W2010063556C185592680 @default.
• W2010063556 hasConceptScore W2010063556C203014093 @default.
• W2010063556 hasConceptScore W2010063556C2776146153 @default.
• W2010063556 hasConceptScore W2010063556C2777064799 @default.
• W2010063556 hasConceptScore W2010063556C2777836882 @default.
• W2010063556 hasConceptScore W2010063556C2778204606 @default.
• W2010063556 hasConceptScore W2010063556C2779338263 @default.
• W2010063556 hasConceptScore W2010063556C2780653079 @default.
• W2010063556 hasConceptScore W2010063556C542903549 @default.
• W2010063556 hasConceptScore W2010063556C55493867 @default.
• W2010063556 hasConceptScore W2010063556C71924100 @default.
• W2010063556 hasConceptScore W2010063556C90924648 @default.
• W2010063556 hasConceptScore W2010063556C98274493 @default.
• W2010063556 hasIssue "4" @default.
• W2010063556 hasLocation W20100635561 @default.
• W2010063556 hasLocation W20100635562 @default.
• W2010063556 hasOpenAccess W2010063556 @default.
• W2010063556 hasPrimaryLocation W20100635561 @default.
• W2010063556 hasRelatedWork W1971365712 @default.
• W2010063556 hasRelatedWork W2001824005 @default.
• W2010063556 hasRelatedWork W2010063556 @default.
• W2010063556 hasRelatedWork W2022674969 @default.
• W2010063556 hasRelatedWork W2138209595 @default.
• W2010063556 hasRelatedWork W2159173527 @default.
• W2010063556 hasRelatedWork W2181737847 @default.
• W2010063556 hasRelatedWork W2286405748 @default.
• W2010063556 hasRelatedWork W2468068468 @default.
• W2010063556 hasRelatedWork W2776242346 @default.

• next