FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010064332> ?p ?o ?g. }

• W2010064332 endingPage "235" @default.
• W2010064332 startingPage "229" @default.
• W2010064332 abstract "Paraoxonase is a serum enzyme with an anti-oxidant function, protecting low density lipoproteins (LDL) from oxidative modifications. Diabetic patients are suggested to be at greater risk of oxidative stress, which may contribute to the significantly higher incidence of vascular disease in this population. Less efficient protection mechanisms may be one feature of the greater susceptibility to oxidation in diabetes. In this context, the present study examined the hypothesis that serum paraoxonase is reduced in type 1 (insulin-dependent) diabetic patients and that the reduction can affect the anti-oxidant capacity of HDL. Serum paraoxonase concentrations and activities were compared in type 1 patients and first degree, non-diabetic relatives with particular attention paid to the confounding effects of paraoxonase gene polymorphisms. In addition, the ability of HDL-paraoxonase to protect low density lipoproteins from oxidation was analysed in an in vitro system. Serum concentrations and enzyme activities of paraoxonase were significantly lower in type 1 patients compared to non-diabetic, first degree relatives. The differences were independent of promoter and coding region polymorphisms, which influence serum concentrations and activities of the enzyme. Overall, paraoxonase concentrations were a mean 13.3+/-4.5% lower (P<0.02) in type 1 patients. Specific activities did not differ between diabetic and non-diabetic groups. The concentration ratios of LDL cholesterol:paraoxonase (1.37+/-0.51 vs. 1.18+/-0.37, P=0.003) and apolipoprotein B:paraoxonase (0.84+/-0.33 vs. 0.71+/-0.40; P=0.012) were significantly higher in diabetic patients, consistent with a reduced capacity to protect LDL from oxidation. In vitro oxidation studies showed that a significantly higher level of lipid hydroperoxides was generated in LDL in the presence of HDL, containing paraoxonase levels equivalent to those of type 1 patients, compared to HDL containing paraoxonase levels equivalent to those of control subjects (mean difference 8.1%, P<0.05). The study demonstrates that serum concentrations of the antioxidant enzyme paraoxonase are significantly lower in type 1 (insulin-dependent) diabetic patients compared to non-diabetic, first-degree relatives, independently of known gene polymorphisms. Concentrations are reduced to an extent that can affect its anti-oxidant capacity. The results are consistent with the contention that modifications to serum paraoxonase in type 1 patients can increase risk of lipoprotein oxidation and, consequently, risk of vascular disease." @default.
• W2010064332 created "2016-06-24" @default.
• W2010064332 creator A5027639037 @default.
• W2010064332 creator A5036145205 @default.
• W2010064332 creator A5040118133 @default.
• W2010064332 creator A5044195709 @default.
• W2010064332 creator A5044748211 @default.
• W2010064332 creator A5063490617 @default.
• W2010064332 date "2001-03-01" @default.
• W2010064332 modified "2023-10-15" @default.
• W2010064332 title "Serum paraoxonase is reduced in type 1 diabetic patients compared to non-diabetic, first degree relatives; influence on the ability of HDL to protect LDL from oxidation" @default.
• W2010064332 cites W1508237750 @default.
• W2010064332 cites W1523119366 @default.
• W2010064332 cites W1671050155 @default.
• W2010064332 cites W1800621346 @default.
• W2010064332 cites W1967607974 @default.
• W2010064332 cites W1978146746 @default.
• W2010064332 cites W1987622744 @default.
• W2010064332 cites W1998358844 @default.
• W2010064332 cites W2001432332 @default.
• W2010064332 cites W2007306216 @default.
• W2010064332 cites W2007752173 @default.
• W2010064332 cites W2012639879 @default.
• W2010064332 cites W2013529909 @default.
• W2010064332 cites W2015600361 @default.
• W2010064332 cites W2015635131 @default.
• W2010064332 cites W2022805316 @default.
• W2010064332 cites W2033661020 @default.
• W2010064332 cites W2037426731 @default.
• W2010064332 cites W2042203706 @default.
• W2010064332 cites W2046946523 @default.
• W2010064332 cites W2048607595 @default.
• W2010064332 cites W2049698305 @default.
• W2010064332 cites W2056746675 @default.
• W2010064332 cites W2057072480 @default.
• W2010064332 cites W2059695123 @default.
• W2010064332 cites W2061663562 @default.
• W2010064332 cites W2066643076 @default.
• W2010064332 cites W2074532601 @default.
• W2010064332 cites W2080486016 @default.
• W2010064332 cites W2081406581 @default.
• W2010064332 cites W2088622017 @default.
• W2010064332 cites W2092913820 @default.
• W2010064332 cites W2115139514 @default.
• W2010064332 cites W2116404316 @default.
• W2010064332 cites W2124098523 @default.
• W2010064332 cites W2129503890 @default.
• W2010064332 cites W2150545098 @default.
• W2010064332 cites W4230461840 @default.
• W2010064332 cites W4231463917 @default.
• W2010064332 cites W4234370789 @default.
• W2010064332 cites W4236702480 @default.
• W2010064332 cites W4249836835 @default.
• W2010064332 cites W967962159 @default.
• W2010064332 doi "https://doi.org/10.1016/s0021-9150(00)00556-6" @default.
• W2010064332 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11223446" @default.
• W2010064332 hasPublicationYear "2001" @default.
• W2010064332 type Work @default.
• W2010064332 sameAs 2010064332 @default.
• W2010064332 citedByCount "118" @default.
• W2010064332 countsByYear W20100643322012 @default.
• W2010064332 countsByYear W20100643322013 @default.
• W2010064332 countsByYear W20100643322014 @default.
• W2010064332 countsByYear W20100643322015 @default.
• W2010064332 countsByYear W20100643322016 @default.
• W2010064332 countsByYear W20100643322017 @default.
• W2010064332 countsByYear W20100643322018 @default.
• W2010064332 countsByYear W20100643322019 @default.
• W2010064332 countsByYear W20100643322020 @default.
• W2010064332 countsByYear W20100643322021 @default.
• W2010064332 countsByYear W20100643322022 @default.
• W2010064332 countsByYear W20100643322023 @default.
• W2010064332 crossrefType "journal-article" @default.
• W2010064332 hasAuthorship W2010064332A5027639037 @default.
• W2010064332 hasAuthorship W2010064332A5036145205 @default.
• W2010064332 hasAuthorship W2010064332A5040118133 @default.
• W2010064332 hasAuthorship W2010064332A5044195709 @default.
• W2010064332 hasAuthorship W2010064332A5044748211 @default.
• W2010064332 hasAuthorship W2010064332A5063490617 @default.
• W2010064332 hasConcept C104317684 @default.
• W2010064332 hasConcept C126322002 @default.
• W2010064332 hasConcept C134018914 @default.
• W2010064332 hasConcept C135763542 @default.
• W2010064332 hasConcept C151730666 @default.
• W2010064332 hasConcept C185592680 @default.
• W2010064332 hasConcept C2776151105 @default.
• W2010064332 hasConcept C2776509667 @default.
• W2010064332 hasConcept C2777180221 @default.
• W2010064332 hasConcept C2778163477 @default.
• W2010064332 hasConcept C2778242859 @default.
• W2010064332 hasConcept C2779343474 @default.
• W2010064332 hasConcept C2779862289 @default.
• W2010064332 hasConcept C2781179581 @default.
• W2010064332 hasConcept C2908647359 @default.
• W2010064332 hasConcept C2910068830 @default.
• W2010064332 hasConcept C37501387 @default.
• W2010064332 hasConcept C55493867 @default.
• W2010064332 hasConcept C555293320 @default.

• next