FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010064452> ?p ?o ?g. }

• W2010064452 endingPage "14" @default.
• W2010064452 startingPage "5" @default.
• W2010064452 abstract "The active transport of ions across a membrane by an ATP-driven electrogenic ion pump is often described by an 'alternate access' model. The position of the binding site is assumed to be unchanged as the binding cavity opens alternatively to the uptake and discharge sides of the membrane. The ion binding affinity is higher on the uptake side of the membrane than on the discharge side. This difference in affinities is related to the maximum transport rate and to the efficiency with which ATP hydrolysis is coupled to active transport. Here we examine the electrostatic contribution to binding affinities, using a simple geometry for a model membrane-protein system, a continuum dielectric approximation, and a numerical method to calculate binding energy as a function of the binding site location. If the binding site is located asymmetrically, being further from the uptake side of the membrane than from the discharge side, there is a significant difference in binding free energy between the uptake and discharge states. This asymmetry can produce differences in affinities that are consistent with those measured for biological active transport systems. These results may account for the observed asymmetric location of the calcium binding site in the calcium ATPases from sarcoplasmic reticulum and from the plasma membrane. Electrostatic energy differences associated with binding site asymmetry may be a general feature of electrogenic transmembrane ion pumps." @default.
• W2010064452 created "2016-06-24" @default.
• W2010064452 creator A5077611406 @default.
• W2010064452 creator A5088307660 @default.
• W2010064452 date "1995-03-01" @default.
• W2010064452 modified "2023-10-17" @default.
• W2010064452 title "Active transport of ions across membranes: energetic role of electrostatics and binding site asymmetry" @default.
• W2010064452 cites W1605242131 @default.
• W2010064452 cites W1971110562 @default.
• W2010064452 cites W1972107705 @default.
• W2010064452 cites W1986230228 @default.
• W2010064452 cites W1989575369 @default.
• W2010064452 cites W1990451546 @default.
• W2010064452 cites W1997432723 @default.
• W2010064452 cites W1997639796 @default.
• W2010064452 cites W2029653284 @default.
• W2010064452 cites W2031806259 @default.
• W2010064452 cites W2032518125 @default.
• W2010064452 cites W2036873028 @default.
• W2010064452 cites W2051555156 @default.
• W2010064452 cites W2051568142 @default.
• W2010064452 cites W2060672012 @default.
• W2010064452 cites W2064948391 @default.
• W2010064452 cites W2069002738 @default.
• W2010064452 cites W2081228375 @default.
• W2010064452 cites W2087159568 @default.
• W2010064452 cites W2088174705 @default.
• W2010064452 cites W2121058955 @default.
• W2010064452 cites W2131181796 @default.
• W2010064452 cites W2175093448 @default.
• W2010064452 cites W2177024335 @default.
• W2010064452 cites W2177655263 @default.
• W2010064452 doi "https://doi.org/10.1016/0005-2736(94)00265-q" @default.
• W2010064452 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7880859" @default.
• W2010064452 hasPublicationYear "1995" @default.
• W2010064452 type Work @default.
• W2010064452 sameAs 2010064452 @default.
• W2010064452 citedByCount "2" @default.
• W2010064452 crossrefType "journal-article" @default.
• W2010064452 hasAuthorship W2010064452A5077611406 @default.
• W2010064452 hasAuthorship W2010064452A5088307660 @default.
• W2010064452 hasBestOaLocation W20100644521 @default.
• W2010064452 hasConcept C107824862 @default.
• W2010064452 hasConcept C117626034 @default.
• W2010064452 hasConcept C121332964 @default.
• W2010064452 hasConcept C12554922 @default.
• W2010064452 hasConcept C141315368 @default.
• W2010064452 hasConcept C145148216 @default.
• W2010064452 hasConcept C147789679 @default.
• W2010064452 hasConcept C178790620 @default.
• W2010064452 hasConcept C181199279 @default.
• W2010064452 hasConcept C184779094 @default.
• W2010064452 hasConcept C185592680 @default.
• W2010064452 hasConcept C23265538 @default.
• W2010064452 hasConcept C2780283098 @default.
• W2010064452 hasConcept C41183919 @default.
• W2010064452 hasConcept C41625074 @default.
• W2010064452 hasConcept C55493867 @default.
• W2010064452 hasConcept C57947595 @default.
• W2010064452 hasConcept C71240020 @default.
• W2010064452 hasConcept C86803240 @default.
• W2010064452 hasConcept C93282013 @default.
• W2010064452 hasConceptScore W2010064452C107824862 @default.
• W2010064452 hasConceptScore W2010064452C117626034 @default.
• W2010064452 hasConceptScore W2010064452C121332964 @default.
• W2010064452 hasConceptScore W2010064452C12554922 @default.
• W2010064452 hasConceptScore W2010064452C141315368 @default.
• W2010064452 hasConceptScore W2010064452C145148216 @default.
• W2010064452 hasConceptScore W2010064452C147789679 @default.
• W2010064452 hasConceptScore W2010064452C178790620 @default.
• W2010064452 hasConceptScore W2010064452C181199279 @default.
• W2010064452 hasConceptScore W2010064452C184779094 @default.
• W2010064452 hasConceptScore W2010064452C185592680 @default.
• W2010064452 hasConceptScore W2010064452C23265538 @default.
• W2010064452 hasConceptScore W2010064452C2780283098 @default.
• W2010064452 hasConceptScore W2010064452C41183919 @default.
• W2010064452 hasConceptScore W2010064452C41625074 @default.
• W2010064452 hasConceptScore W2010064452C55493867 @default.
• W2010064452 hasConceptScore W2010064452C57947595 @default.
• W2010064452 hasConceptScore W2010064452C71240020 @default.
• W2010064452 hasConceptScore W2010064452C86803240 @default.
• W2010064452 hasConceptScore W2010064452C93282013 @default.
• W2010064452 hasIssue "1" @default.
• W2010064452 hasLocation W20100644521 @default.
• W2010064452 hasLocation W20100644522 @default.
• W2010064452 hasOpenAccess W2010064452 @default.
• W2010064452 hasPrimaryLocation W20100644521 @default.
• W2010064452 hasRelatedWork W1984410800 @default.
• W2010064452 hasRelatedWork W1985054064 @default.
• W2010064452 hasRelatedWork W1999284612 @default.
• W2010064452 hasRelatedWork W2065679107 @default.
• W2010064452 hasRelatedWork W2087420281 @default.
• W2010064452 hasRelatedWork W2088601834 @default.
• W2010064452 hasRelatedWork W2104465251 @default.
• W2010064452 hasRelatedWork W2186128014 @default.
• W2010064452 hasRelatedWork W2430075074 @default.
• W2010064452 hasRelatedWork W3216616243 @default.
• W2010064452 hasVolume "1234" @default.

• next