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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010066218> ?p ?o ?g. }

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• W2010066218 abstract "A highly ligand efficient, novel 8-oxo-pyridopyrimidine containing inhibitor of Jak1 and Jak2 isoforms with a pyridone moiety as the hinge-binding motif was discovered. Structure-based design strategies were applied to significantly improve enzyme potency and the polarity of the molecule was adjusted to gain cellular activity. The crystal structures of two representative inhibitors bound to Jak1 were obtained to enable SAR exploration." @default.
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• W2010066218 date "2013-11-01" @default.
• W2010066218 modified "2023-09-25" @default.
• W2010066218 title "Design and evaluation of novel 8-oxo-pyridopyrimidine Jak1/2 inhibitors" @default.
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• W2010066218 doi "https://doi.org/10.1016/j.bmcl.2013.08.082" @default.
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