FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010066525> ?p ?o ?g. }

• W2010066525 endingPage "41" @default.
• W2010066525 startingPage "33" @default.
• W2010066525 abstract "The present study was undertaken to investigate the inhibitory effects of beta-ionone, (-)-menthol, 1,8-cineole and alpha-terpineol on liver microsomal enzymes involved in the biotransformation of xenobiotic substances. The effects of beta-ionone and the foregoing monoterpenoid compounds on the activity of pentoxyresorufin-O-depentilase (PROD), a selective marker for CYP2B1, were determined in a pool of liver microsomes prepared from phenobarbital-treated rats. On the other hand, the inhibitory effects of these substances on the activities of ethoxyresorufin-O-deethylase (EROD), a marker for CYP1A1, and methoxyresorufin-O-demethylase (MROD), a marker for CYP1A2, were investigated in a pool of hepatic microsomes from beta-naphthoflavone-treated rats. Beta-ionone caused a concentration-related reduction of PROD activity with an IC50 value as low as 0.03 microM. The analysis of alterations produced by beta-ionone on PROD kinetic parameters (Lineweaver-Burk double-reciprocal plot) suggested that inhibition is non-competitive (Ki = 89.9 nM). Although being less potent than beta-ionone, 1,8-cineole (IC50 = 4.7 microM), (-)-menthol (IC50 = 10.6 microM) and terpineol (IC50 = 14.8 microM) also proved to be in vitro inhibitors of PROD reaction. Results also revealed that beta-ionone was a weak inhibitor of EROD (IC50 >100 microM) and MROD (IC50 >200 microM). Neither 1,8-cineole nor terpineol--tested in concentrations up to 150 microM--caused any decrease of EROD activity while (-)-menthol, at a concentration as high as 160 microM, produced only a slight reduction of the reaction rate. Terpineol (up to 150 microM) did not induce any reduction of MROD activity while 1,8-cineole (IC50 >300 microM) and (-)-menthol (IC50 >300 microM) caused only slight decreases of the reaction rate. The potent inhibitory effects on CYP2B1 suggest that beta-ionone, and the other monoterpenoids tested, may interfere with the metabolism of xenobiotics which are substrates for this isoenzyme." @default.
• W2010066525 created "2016-06-24" @default.
• W2010066525 creator A5011397630 @default.
• W2010066525 creator A5020990923 @default.
• W2010066525 creator A5087819650 @default.
• W2010066525 date "1999-07-01" @default.
• W2010066525 modified "2023-09-25" @default.
• W2010066525 title "In vitro inhibition of liver monooxygenases by β-ionone, 1,8-cineole, (−)-menthol and terpineol" @default.
• W2010066525 cites W1967837899 @default.
• W2010066525 cites W1969712051 @default.
• W2010066525 cites W1976643302 @default.
• W2010066525 cites W1978450325 @default.
• W2010066525 cites W2005748597 @default.
• W2010066525 cites W2006262882 @default.
• W2010066525 cites W2006668832 @default.
• W2010066525 cites W2017729229 @default.
• W2010066525 cites W2020044202 @default.
• W2010066525 cites W2037294498 @default.
• W2010066525 cites W2051246940 @default.
• W2010066525 cites W2065840609 @default.
• W2010066525 cites W2081118072 @default.
• W2010066525 cites W2094416050 @default.
• W2010066525 cites W2397373668 @default.
• W2010066525 cites W4293247451 @default.
• W2010066525 cites W943584887 @default.
• W2010066525 doi "https://doi.org/10.1016/s0300-483x(99)00043-8" @default.
• W2010066525 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10454222" @default.
• W2010066525 hasPublicationYear "1999" @default.
• W2010066525 type Work @default.
• W2010066525 sameAs 2010066525 @default.
• W2010066525 citedByCount "55" @default.
• W2010066525 countsByYear W20100665252012 @default.
• W2010066525 countsByYear W20100665252013 @default.
• W2010066525 countsByYear W20100665252014 @default.
• W2010066525 countsByYear W20100665252015 @default.
• W2010066525 countsByYear W20100665252016 @default.
• W2010066525 countsByYear W20100665252017 @default.
• W2010066525 countsByYear W20100665252018 @default.
• W2010066525 countsByYear W20100665252019 @default.
• W2010066525 countsByYear W20100665252020 @default.
• W2010066525 countsByYear W20100665252021 @default.
• W2010066525 countsByYear W20100665252023 @default.
• W2010066525 crossrefType "journal-article" @default.
• W2010066525 hasAuthorship W2010066525A5011397630 @default.
• W2010066525 hasAuthorship W2010066525A5020990923 @default.
• W2010066525 hasAuthorship W2010066525A5087819650 @default.
• W2010066525 hasConcept C13002179 @default.
• W2010066525 hasConcept C178790620 @default.
• W2010066525 hasConcept C181199279 @default.
• W2010066525 hasConcept C185592680 @default.
• W2010066525 hasConcept C202751555 @default.
• W2010066525 hasConcept C2777752497 @default.
• W2010066525 hasConcept C2777840627 @default.
• W2010066525 hasConcept C2778032409 @default.
• W2010066525 hasConcept C2780194911 @default.
• W2010066525 hasConcept C27881333 @default.
• W2010066525 hasConcept C43617362 @default.
• W2010066525 hasConcept C526171541 @default.
• W2010066525 hasConcept C55493867 @default.
• W2010066525 hasConcept C71240020 @default.
• W2010066525 hasConcept C86803240 @default.
• W2010066525 hasConcept C87644729 @default.
• W2010066525 hasConcept C98274493 @default.
• W2010066525 hasConceptScore W2010066525C13002179 @default.
• W2010066525 hasConceptScore W2010066525C178790620 @default.
• W2010066525 hasConceptScore W2010066525C181199279 @default.
• W2010066525 hasConceptScore W2010066525C185592680 @default.
• W2010066525 hasConceptScore W2010066525C202751555 @default.
• W2010066525 hasConceptScore W2010066525C2777752497 @default.
• W2010066525 hasConceptScore W2010066525C2777840627 @default.
• W2010066525 hasConceptScore W2010066525C2778032409 @default.
• W2010066525 hasConceptScore W2010066525C2780194911 @default.
• W2010066525 hasConceptScore W2010066525C27881333 @default.
• W2010066525 hasConceptScore W2010066525C43617362 @default.
• W2010066525 hasConceptScore W2010066525C526171541 @default.
• W2010066525 hasConceptScore W2010066525C55493867 @default.
• W2010066525 hasConceptScore W2010066525C71240020 @default.
• W2010066525 hasConceptScore W2010066525C86803240 @default.
• W2010066525 hasConceptScore W2010066525C87644729 @default.
• W2010066525 hasConceptScore W2010066525C98274493 @default.
• W2010066525 hasIssue "1" @default.
• W2010066525 hasLocation W20100665251 @default.
• W2010066525 hasLocation W20100665252 @default.
• W2010066525 hasOpenAccess W2010066525 @default.
• W2010066525 hasPrimaryLocation W20100665251 @default.
• W2010066525 hasRelatedWork W1911389682 @default.
• W2010066525 hasRelatedWork W1986454659 @default.
• W2010066525 hasRelatedWork W2005851276 @default.
• W2010066525 hasRelatedWork W2010066525 @default.
• W2010066525 hasRelatedWork W2037012505 @default.
• W2010066525 hasRelatedWork W2069320234 @default.
• W2010066525 hasRelatedWork W2323939911 @default.
• W2010066525 hasRelatedWork W2338498280 @default.
• W2010066525 hasRelatedWork W2413189091 @default.
• W2010066525 hasRelatedWork W2051493651 @default.
• W2010066525 hasVolume "135" @default.
• W2010066525 isParatext "false" @default.
• W2010066525 isRetracted "false" @default.

• next