FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010069520> ?p ?o ?g. }

• W2010069520 endingPage "875" @default.
• W2010069520 startingPage "868" @default.
• W2010069520 abstract "The dihydropyridine calcium channel blocker, nitrendipine, was studied for its effects on the sodium current of single cultured ventricular cells from neonatal rats. The patch-clamp method of recording whole cell currents was used, and sodium currents were isolated by suppressing potassium and calcium currents. Potassium currents were blocked by replacing potassium with cesium in the internal and external solutions and by adding tetraethylammonium chloride and 4-aminopyridine in the external solution; calcium current was blocked by replacing calcium with cobalt in the external solution. At low frequencies (0.1 Hz), nitrendipine reduced sodium currents without any significant change in the current-voltage relation. The block was dose dependent, and assuming a single occupancy model with complete block, had a half-maximum value of 3 X 10(-6) M at a holding potential of -80 mV where half the sodium channels are activatable. This value is within the range of the Kd's that have been reported for low-affinity dihydropyridine-binding sites found in cardiac sarcolemmal vesicles. In the presence of nitrendipine, the inactivation curve was shifted to hyperpolarized potentials. The block was greater with pulse intervals shorter than 1000 msec, and repriming was prolonged in the presence of the drug. These effects are similar to those of local anesthetics of the tertiary amine class, such as lidocaine. The block was relieved by the dihydropyridine agonist Bay K8644. The results are interpreted as indicating that dihydropyridines react with sodium channels." @default.
• W2010069520 created "2016-06-24" @default.
• W2010069520 creator A5086423794 @default.
• W2010069520 creator A5091383588 @default.
• W2010069520 date "1985-06-01" @default.
• W2010069520 modified "2023-10-18" @default.
• W2010069520 title "The calcium channel blocker nitrendipine blocks sodium channels in neonatal rat cardiac myocytes." @default.
• W2010069520 cites W1975869077 @default.
• W2010069520 cites W1985940938 @default.
• W2010069520 cites W2000434485 @default.
• W2010069520 cites W2004582891 @default.
• W2010069520 cites W2009667219 @default.
• W2010069520 cites W2011160070 @default.
• W2010069520 cites W2012187456 @default.
• W2010069520 cites W2012988898 @default.
• W2010069520 cites W2018931883 @default.
• W2010069520 cites W2020927690 @default.
• W2010069520 cites W2022724192 @default.
• W2010069520 cites W2024954146 @default.
• W2010069520 cites W2026187249 @default.
• W2010069520 cites W2031736892 @default.
• W2010069520 cites W2033282181 @default.
• W2010069520 cites W2037993075 @default.
• W2010069520 cites W2059721218 @default.
• W2010069520 cites W2060079058 @default.
• W2010069520 cites W2067995523 @default.
• W2010069520 cites W2069884282 @default.
• W2010069520 cites W2077936658 @default.
• W2010069520 cites W2080962219 @default.
• W2010069520 cites W2095443790 @default.
• W2010069520 cites W2115052737 @default.
• W2010069520 cites W2116411564 @default.
• W2010069520 cites W2116544026 @default.
• W2010069520 cites W2123184686 @default.
• W2010069520 cites W2126997063 @default.
• W2010069520 cites W2128265835 @default.
• W2010069520 cites W2137067311 @default.
• W2010069520 cites W2155932859 @default.
• W2010069520 cites W2412661964 @default.
• W2010069520 cites W2483527836 @default.
• W2010069520 cites W4237593635 @default.
• W2010069520 cites W4241622970 @default.
• W2010069520 doi "https://doi.org/10.1161/01.res.56.6.868" @default.
• W2010069520 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2408778" @default.
• W2010069520 hasPublicationYear "1985" @default.
• W2010069520 type Work @default.
• W2010069520 sameAs 2010069520 @default.
• W2010069520 citedByCount "105" @default.
• W2010069520 countsByYear W20100695202012 @default.
• W2010069520 countsByYear W20100695202013 @default.
• W2010069520 countsByYear W20100695202014 @default.
• W2010069520 countsByYear W20100695202016 @default.
• W2010069520 countsByYear W20100695202017 @default.
• W2010069520 countsByYear W20100695202018 @default.
• W2010069520 countsByYear W20100695202019 @default.
• W2010069520 countsByYear W20100695202020 @default.
• W2010069520 crossrefType "journal-article" @default.
• W2010069520 hasAuthorship W2010069520A5086423794 @default.
• W2010069520 hasAuthorship W2010069520A5091383588 @default.
• W2010069520 hasBestOaLocation W20100695201 @default.
• W2010069520 hasConcept C12554922 @default.
• W2010069520 hasConcept C178790620 @default.
• W2010069520 hasConcept C185592680 @default.
• W2010069520 hasConcept C2780548744 @default.
• W2010069520 hasConcept C2780918503 @default.
• W2010069520 hasConcept C2781212610 @default.
• W2010069520 hasConcept C2781295685 @default.
• W2010069520 hasConcept C2781391105 @default.
• W2010069520 hasConcept C42219234 @default.
• W2010069520 hasConcept C50952357 @default.
• W2010069520 hasConcept C517785266 @default.
• W2010069520 hasConcept C519063684 @default.
• W2010069520 hasConcept C537181965 @default.
• W2010069520 hasConcept C71924100 @default.
• W2010069520 hasConcept C86803240 @default.
• W2010069520 hasConcept C98274493 @default.
• W2010069520 hasConceptScore W2010069520C12554922 @default.
• W2010069520 hasConceptScore W2010069520C178790620 @default.
• W2010069520 hasConceptScore W2010069520C185592680 @default.
• W2010069520 hasConceptScore W2010069520C2780548744 @default.
• W2010069520 hasConceptScore W2010069520C2780918503 @default.
• W2010069520 hasConceptScore W2010069520C2781212610 @default.
• W2010069520 hasConceptScore W2010069520C2781295685 @default.
• W2010069520 hasConceptScore W2010069520C2781391105 @default.
• W2010069520 hasConceptScore W2010069520C42219234 @default.
• W2010069520 hasConceptScore W2010069520C50952357 @default.
• W2010069520 hasConceptScore W2010069520C517785266 @default.
• W2010069520 hasConceptScore W2010069520C519063684 @default.
• W2010069520 hasConceptScore W2010069520C537181965 @default.
• W2010069520 hasConceptScore W2010069520C71924100 @default.
• W2010069520 hasConceptScore W2010069520C86803240 @default.
• W2010069520 hasConceptScore W2010069520C98274493 @default.
• W2010069520 hasIssue "6" @default.
• W2010069520 hasLocation W20100695201 @default.
• W2010069520 hasLocation W20100695202 @default.
• W2010069520 hasOpenAccess W2010069520 @default.
• W2010069520 hasPrimaryLocation W20100695201 @default.
• W2010069520 hasRelatedWork W1987312691 @default.

• next