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- W2010070710 abstract "Abstract Oxidative phosphorylation and oxidation of NAD+-linked substrates by rat heart mitochondria were depressed by 6.75 × 10−5 M perhexiline maleate (PM), while the succinate oxidation was increased to 320 per cent activity. The drug had no effect on mitochondrial succinic and malate dehydrogenase, NADH-ferricyanide reductase and NADH-CoQ reductase (340 nm); therefore, NADH-oxidase, mitochondrial electron-transporting particles (EP1), NADH-CoQ reductase (550 nm) and aspartate aminotransferase were inhibited. It is suggested that PM would act. preventing the reoxidation of NADH+ + H+ through the respiratory chain." @default.
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- W2010070710 date "1976-11-01" @default.
- W2010070710 modified "2023-09-24" @default.
- W2010070710 title "Possible mechanism of action of perhexiline maleate on heart mitochondria" @default.
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- W2010070710 doi "https://doi.org/10.1016/0006-2952(76)90032-0" @default.
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