Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010072495> ?p ?o ?g. }
- W2010072495 endingPage "S46" @default.
- W2010072495 startingPage "S46" @default.
- W2010072495 abstract "Postnatal growth of the mouse adrenal gland shows a characteristic gender-dependent pattern, resulting in an almost two-fold higher adrenal weight in 11-week-old female versus male mice. We demonstrated that the higher weight of the adrenal glands in female mice is due to a significantly (p<0.05) increased growth rate in female mice and a shorter growth phase of the adrenal glands in male mice (p<0.05). To address the signaling mechanisms underlying these differential growth patterns, we evaluated the phosphorylation levels of p44/42 and p38 MAPK. In female mice, age dependent reductions of p38 MAPK phosphorylation were found between week 3 and week 9 (47% reduction; p<0.05). At the age of 11 weeks the p38 MAPK phosphorylation level in female adrenal glands was about 60% lower than in the male counterparts (p<0.01). Similarly the phosphorylation level of p44/42 MAPK was 50% lower in female adrenal glands (p<0.001). Reduced activation of p44/42 MAPK was also observed after growth stimulation of the adrenal glands in male mice after ACTH treatment (-36%; p<0.001) or by expression of a growth hormone transgene (-34%; p<0.001), while p38 MAPK, JNK or PDK1 activation were unaffected. From our findings in three independent mouse models where partial deactivation of p44/42 MAPK was observed under conditions of elevated growth we suggest a function of p44/42 MAPK for adrenal growth and a role of p44/42 MAPK for the integration of different endocrine stimuli." @default.
- W2010072495 created "2016-06-24" @default.
- W2010072495 creator A5002755097 @default.
- W2010072495 creator A5014771501 @default.
- W2010072495 creator A5024292257 @default.
- W2010072495 creator A5060400236 @default.
- W2010072495 creator A5063796458 @default.
- W2010072495 creator A5074127722 @default.
- W2010072495 creator A5088999106 @default.
- W2010072495 date "2008-09-01" @default.
- W2010072495 modified "2023-09-26" @default.
- W2010072495 title "P-64 Decreased p44/42 MAPK phosphorylation in gender- or hormone-related but not during age-related adrenal gland growth in mice" @default.
- W2010072495 cites W1964929131 @default.
- W2010072495 cites W1965909642 @default.
- W2010072495 cites W1966260349 @default.
- W2010072495 cites W1972541439 @default.
- W2010072495 cites W1975381297 @default.
- W2010072495 cites W1979913622 @default.
- W2010072495 cites W1998809668 @default.
- W2010072495 cites W2004954728 @default.
- W2010072495 cites W2009549069 @default.
- W2010072495 cites W2016300868 @default.
- W2010072495 cites W2017735744 @default.
- W2010072495 cites W2019053581 @default.
- W2010072495 cites W2029334700 @default.
- W2010072495 cites W2032042625 @default.
- W2010072495 cites W2034727575 @default.
- W2010072495 cites W2037181103 @default.
- W2010072495 cites W2039901870 @default.
- W2010072495 cites W2040757434 @default.
- W2010072495 cites W2045655020 @default.
- W2010072495 cites W2047309716 @default.
- W2010072495 cites W2047934167 @default.
- W2010072495 cites W2054343869 @default.
- W2010072495 cites W2059459109 @default.
- W2010072495 cites W2060168299 @default.
- W2010072495 cites W2061806445 @default.
- W2010072495 cites W2074340418 @default.
- W2010072495 cites W2079786905 @default.
- W2010072495 cites W2080958662 @default.
- W2010072495 cites W2082182742 @default.
- W2010072495 cites W2084734831 @default.
- W2010072495 cites W2085742235 @default.
- W2010072495 cites W2086676353 @default.
- W2010072495 cites W2087867186 @default.
- W2010072495 cites W2090663991 @default.
- W2010072495 cites W2100646904 @default.
- W2010072495 cites W2109960702 @default.
- W2010072495 cites W2112253466 @default.
- W2010072495 cites W2122231684 @default.
- W2010072495 cites W2123553649 @default.
- W2010072495 cites W2125486996 @default.
- W2010072495 cites W2127540519 @default.
- W2010072495 cites W2130453574 @default.
- W2010072495 cites W2132182803 @default.
- W2010072495 cites W2133049275 @default.
- W2010072495 cites W2152698264 @default.
- W2010072495 cites W2156688148 @default.
- W2010072495 cites W2162348930 @default.
- W2010072495 cites W2171823263 @default.
- W2010072495 cites W2415607846 @default.
- W2010072495 cites W2418327843 @default.
- W2010072495 doi "https://doi.org/10.1016/s1096-6374(08)70149-7" @default.
- W2010072495 hasPublicationYear "2008" @default.
- W2010072495 type Work @default.
- W2010072495 sameAs 2010072495 @default.
- W2010072495 citedByCount "2" @default.
- W2010072495 crossrefType "journal-article" @default.
- W2010072495 hasAuthorship W2010072495A5002755097 @default.
- W2010072495 hasAuthorship W2010072495A5014771501 @default.
- W2010072495 hasAuthorship W2010072495A5024292257 @default.
- W2010072495 hasAuthorship W2010072495A5060400236 @default.
- W2010072495 hasAuthorship W2010072495A5063796458 @default.
- W2010072495 hasAuthorship W2010072495A5074127722 @default.
- W2010072495 hasAuthorship W2010072495A5088999106 @default.
- W2010072495 hasConcept C11960822 @default.
- W2010072495 hasConcept C126322002 @default.
- W2010072495 hasConcept C134018914 @default.
- W2010072495 hasConcept C24998067 @default.
- W2010072495 hasConcept C2780694816 @default.
- W2010072495 hasConcept C46699223 @default.
- W2010072495 hasConcept C51551487 @default.
- W2010072495 hasConcept C57074206 @default.
- W2010072495 hasConcept C71315377 @default.
- W2010072495 hasConcept C71924100 @default.
- W2010072495 hasConcept C86803240 @default.
- W2010072495 hasConcept C95444343 @default.
- W2010072495 hasConceptScore W2010072495C11960822 @default.
- W2010072495 hasConceptScore W2010072495C126322002 @default.
- W2010072495 hasConceptScore W2010072495C134018914 @default.
- W2010072495 hasConceptScore W2010072495C24998067 @default.
- W2010072495 hasConceptScore W2010072495C2780694816 @default.
- W2010072495 hasConceptScore W2010072495C46699223 @default.
- W2010072495 hasConceptScore W2010072495C51551487 @default.
- W2010072495 hasConceptScore W2010072495C57074206 @default.
- W2010072495 hasConceptScore W2010072495C71315377 @default.
- W2010072495 hasConceptScore W2010072495C71924100 @default.
- W2010072495 hasConceptScore W2010072495C86803240 @default.